Acute Hepatitis and Pneumonitis Caused by Disseminated Bacillus Calmette-Guérin Infection

Intravesical instillation of Bacillus Calmette-Guérin (BCG) is the treatment of choice for superficial bladder carcinoma. We report a case of disseminated BCG infection in an early stage bladder cancer patient that initially presented with hepatitis followed by pneumonitis and sepsis. A complete cli...

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Autores principales: Dibs, Khaled, Shehadeh, Ihab, Abu Atta, Osama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Gastroenterology 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748205/
https://www.ncbi.nlm.nih.gov/pubmed/26958569
http://dx.doi.org/10.14309/crj.2016.23
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author Dibs, Khaled
Shehadeh, Ihab
Abu Atta, Osama
author_facet Dibs, Khaled
Shehadeh, Ihab
Abu Atta, Osama
author_sort Dibs, Khaled
collection PubMed
description Intravesical instillation of Bacillus Calmette-Guérin (BCG) is the treatment of choice for superficial bladder carcinoma. We report a case of disseminated BCG infection in an early stage bladder cancer patient that initially presented with hepatitis followed by pneumonitis and sepsis. A complete clinical response was achieved in 14 days with anti-mycobacterial therapy and prednisolone. Disseminated BCG is a rare treatment complication and is likely a combination of direct infection and hypersensitivity.
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spelling pubmed-47482052016-03-08 Acute Hepatitis and Pneumonitis Caused by Disseminated Bacillus Calmette-Guérin Infection Dibs, Khaled Shehadeh, Ihab Abu Atta, Osama ACG Case Rep J Case Report Intravesical instillation of Bacillus Calmette-Guérin (BCG) is the treatment of choice for superficial bladder carcinoma. We report a case of disseminated BCG infection in an early stage bladder cancer patient that initially presented with hepatitis followed by pneumonitis and sepsis. A complete clinical response was achieved in 14 days with anti-mycobacterial therapy and prednisolone. Disseminated BCG is a rare treatment complication and is likely a combination of direct infection and hypersensitivity. American College of Gastroenterology 2016-01-20 /pmc/articles/PMC4748205/ /pubmed/26958569 http://dx.doi.org/10.14309/crj.2016.23 Text en Copyright © Dibs et al. This is an open-access article. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Case Report
Dibs, Khaled
Shehadeh, Ihab
Abu Atta, Osama
Acute Hepatitis and Pneumonitis Caused by Disseminated Bacillus Calmette-Guérin Infection
title Acute Hepatitis and Pneumonitis Caused by Disseminated Bacillus Calmette-Guérin Infection
title_full Acute Hepatitis and Pneumonitis Caused by Disseminated Bacillus Calmette-Guérin Infection
title_fullStr Acute Hepatitis and Pneumonitis Caused by Disseminated Bacillus Calmette-Guérin Infection
title_full_unstemmed Acute Hepatitis and Pneumonitis Caused by Disseminated Bacillus Calmette-Guérin Infection
title_short Acute Hepatitis and Pneumonitis Caused by Disseminated Bacillus Calmette-Guérin Infection
title_sort acute hepatitis and pneumonitis caused by disseminated bacillus calmette-guérin infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748205/
https://www.ncbi.nlm.nih.gov/pubmed/26958569
http://dx.doi.org/10.14309/crj.2016.23
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