Cargando…

Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition

Cognitive dysfunction is a core feature of dementia and a prominent feature in psychiatric disease. As non-redundant regulators of intracellular cAMP gradients, phosphodiesterases (PDE) mediate fundamental aspects of brain function relevant to learning, memory, and higher cognitive functions. Phosph...

Descripción completa

Detalles Bibliográficos
Autores principales:	McGirr, Alexander, Lipina, Tatiana V, Mun, Ho-Suk, Georgiou, John, Al-Amri, Ahmed H, Ng, Enoch, Zhai, Dongxu, Elliott, Christina, Cameron, Ryan T, Mullins, Jonathan GL, Liu, Fang, Baillie, George S, Clapcote, Steven J, Roder, John C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748432/ https://www.ncbi.nlm.nih.gov/pubmed/26272049 http://dx.doi.org/10.1038/npp.2015.240

Ejemplares similares

Self-directed exploration provides a Ncs1-dependent learning bonus
por: Mun, Ho-Suk, et al.
Publicado: (2015)

Ultrasonic Vocalizations in Mice During Exploratory Behavior are Context-Dependent
por: Mun, Ho-Suk, et al.
Publicado: (2015)

Prophylactic Valproic Acid Treatment Prevents Schizophrenia-Related Behaviour in Disc1-L100P Mutant Mice
por: Lipina, Tatiana V., et al.
Publicado: (2012)

Unraveling the epigenomic and transcriptomic interplay during alcohol-induced anxiolysis
por: Krishnan, Harish R., et al.
Publicado: (2022)

Notes of a Rattle-Snake Bite Admitted into the Ill. Gen. Hospital
por: McGirr, John E.
Publicado: (1852)

McGirr on Abdominal Movements
por: McGirr, John E.
Publicado: (1848)

Inoculation in Rubeola
por: McGirr, John E.
Publicado: (1851)

Identification of a Role for the Ventral Hippocampus in Neuropeptide S-Elicited Anxiolysis
por: Dine, Julien, et al.
Publicado: (2013)

Anti-aggressive effects of neuropeptide S independent of anxiolysis in male rats
por: Beiderbeck, Daniela I., et al.
Publicado: (2014)

Chronic Mild Stress (CMS) in Mice: Of Anhedonia, ‘Anomalous Anxiolysis’ and Activity
por: Schweizer, Martin C., et al.
Publicado: (2009)

Anxiolysis in the Surgical Management of a Compound Odontoma in a Pediatric Patient
por: Poli, Pier Paolo, et al.
Publicado: (2019)

Alternaria keratitis after corneal crosslinking
por: McGirr, Samantha, et al.
Publicado: (2020)

The Effect of Computer Tablets on the Need for Medical Anxiolysis in Children in an Ambulatory Surgical Center
por: Farlie, Kerry H, et al.
Publicado: (2023)

The Value of Intermittent Venous Occlusion. Its Effect on Local Muscle Circulation as Determined by the Clearance of Radioactive Sodium (Sodium 24)
por: McGirr, E. M.
Publicado: (1952)

Cases and Observations on the Use of Strychnia in Intermittent Fevers
por: McGirr, J. E.
Publicado: (1848)

Etherization Applied to Midwifery
por: McGirr, J. E.
Publicado: (1847)

Abdominal Movements with Reference to Pregnancy—their Nature and Cause
por: McGirr, J. E.
Publicado: (1848)

High-fat diet prevents adaptive peripartum-associated adrenal gland plasticity and anxiolysis
por: Perani, Clara V., et al.
Publicado: (2015)

Drugs for dementia: the first year. An audit of prescribing practice.
por: McGirr, G., et al.
Publicado: (2000)

Preoperative anxiolysis in pediatric population: A comparative study between oral midazolam and oral ketamine
por: Sen, Sreyashi, et al.
Publicado: (2013)

NMDA-receptor-dependent plasticity in the bed nucleus of the stria terminalis triggers long-term anxiolysis
por: Glangetas, Christelle, et al.
Publicado: (2017)

From an Empty Stomach to Anxiolysis: Molecular and Behavioral Assessment of Sex Differences in the Ghrelin Axis of Rats
por: Börchers, Stina, et al.
Publicado: (2022)

Low-dose midazolam for anxiolysis for pregnant women undergoing cesarean delivery: a randomized trial
por: Oliveira, Pedro Solfa Campos, et al.
Publicado: (2021)

Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice
por: Dachtler, James, et al.
Publicado: (2016)

Screening for Obesity in Reproductive-Aged Women
por: Zera, Chloe, et al.
Publicado: (2011)

Parallel evolution of gene expression between trophic specialists despite divergent genotypes and morphologies
por: McGirr, Joseph A., et al.
Publicado: (2018)

Hybrid gene misregulation in multiple developing tissues within a recent adaptive radiation of Cyprinodon pupfishes
por: McGirr, Joseph A., et al.
Publicado: (2019)

Few Fixed Variants between Trophic Specialist Pupfish Species Reveal Candidate Cis-Regulatory Alleles Underlying Rapid Craniofacial Divergence
por: McGirr, Joseph A, et al.
Publicado: (2020)

Comparative Study of Oral Gabapentin, Pregabalin, and Clonidine as Premedication for Anxiolysis, Sedation, and Attenuation of Pressor Response to Endotracheal Intubation
por: Waikar, Chandrakant, et al.
Publicado: (2017)

Assessment of Social Interaction Behaviors
por: Kaidanovich-Beilin, Oksana, et al.
Publicado: (2011)

α7nAchR/NMDAR coupling affects NMDAR function and object recognition
por: Li, Shupeng, et al.
Publicado: (2013)

Characterization of Cognitive Deficits in Mice With an Alternating Hemiplegia-Linked Mutation
por: Kirshenbaum, Greer S., et al.
Publicado: (2015)

Transgenic rescue of phenotypic deficits in a mouse model of alternating hemiplegia of childhood
por: Kirshenbaum, Greer S., et al.
Publicado: (2015)

An exploratory non-randomized study of a 3-month electronic nicotine delivery system (ENDS) intervention with people accessing a homeless supported temporary accommodation service (STA) in Ireland
por: Scheibein, Florian, et al.
Publicado: (2020)

Correction to: An exploratory non-randomized study of a 3-month electronic nicotine delivery system (ENDS) intervention with people accessing a homeless supported temporary accommodation service (STA) in Ireland
por: Scheibein, Florian, et al.
Publicado: (2021)

The Accuracy of Self-Perception of Obesity in a Rural Australian Population: A Cross-Sectional Study
por: Seth, Nimish, et al.
Publicado: (2022)

Erratum: Comparative Study of Oral Gabapentin, Pregabalin, and Clonidine as Premedication for Anxiolysis, Sedation, and Attenuation of Pressor Response to Endotracheal Intubation
Publicado: (2017)

How to Investigate the Origins of Novelty: Insights Gained from Genetic, Behavioral, and Fitness Perspectives
por: Martin, C H, et al.
Publicado: (2019)

Estimation of the Underlying Burden of Pertussis in Adolescents and Adults in Southern Ontario, Canada
por: McGirr, Ashleigh A., et al.
Publicado: (2013)

Comment on: ‘Clinical and Economic Impact of a Potential Switch from 13-Valent to 10-Valent Pneumococcal Conjugate Infant Vaccination in Canada’, Wilson et al., 22 June 2018
por: McGirr, Ashleigh, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_1pfps083tp1lied56ftke47ea3