Metformin improves the angiogenic potential of human CD34(+) cells co-incident with downregulating CXCL10 and TIMP1 gene expression and increasing VEGFA under hyperglycemia and hypoxia within a therapeutic window for myocardial infarction

BACKGROUND: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with diabetes mellitus (DM). To identify the most effective treatment for CVD, it is paramount to understand the mechanism behind cardioprotective therapies. Although metformin has been shown to redu...

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Detalles Bibliográficos
Autores principales: Bakhashab, Sherin, Ahmed, Fahad W., Schulten, Hans-Juergen, Bashir, Ayat, Karim, Sajjad, Al-Malki, Abdulrahman L., Gari, Mamdooh A., Abuzenadah, Adel M., Chaudhary, Adeel G., Alqahtani, Mohammed H., Lary, Sahira, Ahmed, Farid, Weaver, Jolanta U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748498/
https://www.ncbi.nlm.nih.gov/pubmed/26861446
http://dx.doi.org/10.1186/s12933-016-0344-2

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