Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo

BACKGROUND: Prions and amyloid-β (Aβ) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, PrP-1-dependent signals control cell-cell adhesion via a tyrosine phosphorylation-depende...

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Detalles Bibliográficos
Autores principales: Sempou, Emily, Biasini, Emiliano, Pinzón-Olejua, Alejandro, Harris, David A., Málaga-Trillo, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748561/
https://www.ncbi.nlm.nih.gov/pubmed/26860872
http://dx.doi.org/10.1186/s13024-016-0076-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748561/
https://www.ncbi.nlm.nih.gov/pubmed/26860872
http://dx.doi.org/10.1186/s13024-016-0076-5

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