Assessment of drug content uniformity of atropine sulfate triturate by liquid chromatography–tandem mass spectrometry, X-ray powder diffraction, and Raman chemical imaging

BACKGROUND: Atropine sulfate is an anticholinergic agent for treatment of hypertrophic pyloric stenosis and is orally administrated as a triturate with lactose hydrate. Because of the low safety margin of atropine sulfate, triturate uniformity is a key safety factor. In this study, we assessed the u...

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Detalles Bibliográficos
Autores principales: Moriyama, Kei, Takami, Yoichiro, Uozumi, Natsuki, Okuda, Akiko, Yamashita, Mayumi, Yokomizo, Rie, Shimada, Kenichi, Egawa, Takashi, Kamei, Takehito, Takayanagi, Kazunobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748566/
https://www.ncbi.nlm.nih.gov/pubmed/26865984
http://dx.doi.org/10.1186/s40780-016-0038-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748566/
https://www.ncbi.nlm.nih.gov/pubmed/26865984
http://dx.doi.org/10.1186/s40780-016-0038-7

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