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Inflammatory myofibroblastic tumor of the lung in pregnancy mimicking carcinoid tumor

Inflammatory myofibroblastic tumors (IMT) are uncommon neoplasms of the lung in adults. They constitute less than 1% of all lung neoplasms and usually present as parenchymal masses. Diagnosis requires a high index of suspicion. They are characterized by spindle-shaped tumor cells (fibroblasts/myofib...

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Autores principales: Maturu, Venkata Nagarjuna, Bal, Amanjit, Singh, Navneet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748673/
https://www.ncbi.nlm.nih.gov/pubmed/26933315
http://dx.doi.org/10.4103/0970-2113.173058
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author Maturu, Venkata Nagarjuna
Bal, Amanjit
Singh, Navneet
author_facet Maturu, Venkata Nagarjuna
Bal, Amanjit
Singh, Navneet
author_sort Maturu, Venkata Nagarjuna
collection PubMed
description Inflammatory myofibroblastic tumors (IMT) are uncommon neoplasms of the lung in adults. They constitute less than 1% of all lung neoplasms and usually present as parenchymal masses. Diagnosis requires a high index of suspicion. They are characterized by spindle-shaped tumor cells (fibroblasts/myofibroblasts) in a background of lymphoplasmacytic infiltrate. About 50% of the tumors harbor an ALK gene rearrangement. They have to be differentiated from inflammatory pseudotumors (IPT), which show increased number of IgG4 plasma cells on immunostaining and are negative for anaplastic lymphoma kinase (ALK) protein. Herein, we present a case of a 28-year old female who presented with hemoptysis and was diagnosed with an IMT of lung in the first trimester of pregnancy. We have not only reviewed the occurrence of IMT during pregnancy but also discuss the management options for IMT during pregnancy.
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spelling pubmed-47486732016-03-01 Inflammatory myofibroblastic tumor of the lung in pregnancy mimicking carcinoid tumor Maturu, Venkata Nagarjuna Bal, Amanjit Singh, Navneet Lung India Case Report Inflammatory myofibroblastic tumors (IMT) are uncommon neoplasms of the lung in adults. They constitute less than 1% of all lung neoplasms and usually present as parenchymal masses. Diagnosis requires a high index of suspicion. They are characterized by spindle-shaped tumor cells (fibroblasts/myofibroblasts) in a background of lymphoplasmacytic infiltrate. About 50% of the tumors harbor an ALK gene rearrangement. They have to be differentiated from inflammatory pseudotumors (IPT), which show increased number of IgG4 plasma cells on immunostaining and are negative for anaplastic lymphoma kinase (ALK) protein. Herein, we present a case of a 28-year old female who presented with hemoptysis and was diagnosed with an IMT of lung in the first trimester of pregnancy. We have not only reviewed the occurrence of IMT during pregnancy but also discuss the management options for IMT during pregnancy. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4748673/ /pubmed/26933315 http://dx.doi.org/10.4103/0970-2113.173058 Text en Copyright: © Lung India http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Maturu, Venkata Nagarjuna
Bal, Amanjit
Singh, Navneet
Inflammatory myofibroblastic tumor of the lung in pregnancy mimicking carcinoid tumor
title Inflammatory myofibroblastic tumor of the lung in pregnancy mimicking carcinoid tumor
title_full Inflammatory myofibroblastic tumor of the lung in pregnancy mimicking carcinoid tumor
title_fullStr Inflammatory myofibroblastic tumor of the lung in pregnancy mimicking carcinoid tumor
title_full_unstemmed Inflammatory myofibroblastic tumor of the lung in pregnancy mimicking carcinoid tumor
title_short Inflammatory myofibroblastic tumor of the lung in pregnancy mimicking carcinoid tumor
title_sort inflammatory myofibroblastic tumor of the lung in pregnancy mimicking carcinoid tumor
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748673/
https://www.ncbi.nlm.nih.gov/pubmed/26933315
http://dx.doi.org/10.4103/0970-2113.173058
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