A DEAD-box RNA helicase promotes thermodynamic equilibration of kinetically trapped RNA structures in vivo

RNAs must assemble into specific structures in order to carry out their biological functions, but in vitro RNA folding reactions produce multiple misfolded structures that fail to exchange with functional structures on biological time scales. We used carefully designed self-cleaving mRNAs that assem...

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Detalles Bibliográficos
Autores principales: Ruminski, Dana J., Watson, Peter Y., Mahen, Elisabeth M., Fedor, Martha J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748819/
https://www.ncbi.nlm.nih.gov/pubmed/26759451
http://dx.doi.org/10.1261/rna.055178.115

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