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Recognition of Damaged DNA for Nucleotide Excision Repair: A Correlated Motion Mechanism with a Mismatched cis-syn Thymine Dimer Lesion

[Image: see text] Mammalian global genomic nucleotide excision repair requires lesion recognition by XPC, whose detailed binding mechanism remains to be elucidated. Here we have delineated the dynamic molecular pathway and energetics of lesion-specific and productive binding by the Rad4/yeast XPC le...

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Detalles Bibliográficos
Autores principales:	Mu, Hong, Geacintov, Nicholas E., Zhang, Yingkai, Broyde, Suse
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748833/ https://www.ncbi.nlm.nih.gov/pubmed/26270861 http://dx.doi.org/10.1021/acs.biochem.5b00840

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