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Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer's Type Dementia
Aim. To asses both choroidal thickness differences among Alzheimer's type dementia (ATD) patients, mild cognitive impairment (MCI) patients, and healthy control (C) subjects and choroidal thickness relationships with cognitive performance. Methods. A total of 246 eyes of 123 people (41 ATD, 38...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748862/ https://www.ncbi.nlm.nih.gov/pubmed/26925259 http://dx.doi.org/10.1155/2016/7291257 |
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author | Bulut, Mehmet Yaman, Aylin Erol, Muhammet Kazim Kurtuluş, Fatma Toslak, Devrim Doğan, Berna Turgut Çoban, Deniz Kaya Başar, Ebru |
author_facet | Bulut, Mehmet Yaman, Aylin Erol, Muhammet Kazim Kurtuluş, Fatma Toslak, Devrim Doğan, Berna Turgut Çoban, Deniz Kaya Başar, Ebru |
author_sort | Bulut, Mehmet |
collection | PubMed |
description | Aim. To asses both choroidal thickness differences among Alzheimer's type dementia (ATD) patients, mild cognitive impairment (MCI) patients, and healthy control (C) subjects and choroidal thickness relationships with cognitive performance. Methods. A total of 246 eyes of 123 people (41 ATD, 38 MCI, and 44 healthy C subjects) were included in this study. Complete ophthalmological and neurological examination was performed in all subjects. Choroidal thicknesses (CT) were measured at seven locations: the fovea, 500-1500-3000 μm temporal and 500-1500-3000 μm nasal to the fovea by enhanced depth imaging optical coherence tomography (EDI-OCT). Detailed neurological examination including mini mental state examination (MMSE) test which evaluates the cognitive function was applied to all participants. Results. The ages and genders of all participants were similar in all groups. Compared with healthy C subjects, the CT measurements at all regions were significantly thinner both in patients with ATD and in patients with MCI than in healthy C subjects (p < 0.05). The MMSE scores were significantly different among ATD patients, MCI patients, and healthy C subjects. They were 19.3 ± 1.8, 24.8 ± 0.9, and 27.6 ± 1.2 in ATD, MCI, and healthy controls, respectively (p < 0.001). There were also significant correlation between MMSE score and choroidal thickness at each location (p < 0.05). Conclusions. CT was reduced in ATD patients and MCI patients. Since vascular structures were affected in ATD patients and MCI patients, they had thin CT. Besides CT was correlated with degree of cognitive impairment. Therefore CT may be a new biomarker in diagnosis and follow-up of MCI and ATD patients. |
format | Online Article Text |
id | pubmed-4748862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-47488622016-02-28 Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer's Type Dementia Bulut, Mehmet Yaman, Aylin Erol, Muhammet Kazim Kurtuluş, Fatma Toslak, Devrim Doğan, Berna Turgut Çoban, Deniz Kaya Başar, Ebru J Ophthalmol Research Article Aim. To asses both choroidal thickness differences among Alzheimer's type dementia (ATD) patients, mild cognitive impairment (MCI) patients, and healthy control (C) subjects and choroidal thickness relationships with cognitive performance. Methods. A total of 246 eyes of 123 people (41 ATD, 38 MCI, and 44 healthy C subjects) were included in this study. Complete ophthalmological and neurological examination was performed in all subjects. Choroidal thicknesses (CT) were measured at seven locations: the fovea, 500-1500-3000 μm temporal and 500-1500-3000 μm nasal to the fovea by enhanced depth imaging optical coherence tomography (EDI-OCT). Detailed neurological examination including mini mental state examination (MMSE) test which evaluates the cognitive function was applied to all participants. Results. The ages and genders of all participants were similar in all groups. Compared with healthy C subjects, the CT measurements at all regions were significantly thinner both in patients with ATD and in patients with MCI than in healthy C subjects (p < 0.05). The MMSE scores were significantly different among ATD patients, MCI patients, and healthy C subjects. They were 19.3 ± 1.8, 24.8 ± 0.9, and 27.6 ± 1.2 in ATD, MCI, and healthy controls, respectively (p < 0.001). There were also significant correlation between MMSE score and choroidal thickness at each location (p < 0.05). Conclusions. CT was reduced in ATD patients and MCI patients. Since vascular structures were affected in ATD patients and MCI patients, they had thin CT. Besides CT was correlated with degree of cognitive impairment. Therefore CT may be a new biomarker in diagnosis and follow-up of MCI and ATD patients. Hindawi Publishing Corporation 2016 2016-01-11 /pmc/articles/PMC4748862/ /pubmed/26925259 http://dx.doi.org/10.1155/2016/7291257 Text en Copyright © 2016 Mehmet Bulut et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bulut, Mehmet Yaman, Aylin Erol, Muhammet Kazim Kurtuluş, Fatma Toslak, Devrim Doğan, Berna Turgut Çoban, Deniz Kaya Başar, Ebru Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer's Type Dementia |
title | Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer's Type Dementia |
title_full | Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer's Type Dementia |
title_fullStr | Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer's Type Dementia |
title_full_unstemmed | Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer's Type Dementia |
title_short | Choroidal Thickness in Patients with Mild Cognitive Impairment and Alzheimer's Type Dementia |
title_sort | choroidal thickness in patients with mild cognitive impairment and alzheimer's type dementia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748862/ https://www.ncbi.nlm.nih.gov/pubmed/26925259 http://dx.doi.org/10.1155/2016/7291257 |
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