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Vaginal Mucosal Homeostatic Response May Determine Pregnancy Outcome in Women With Bacterial Vaginosis: A Pilot Study

Bacterial vaginosis (BV) is considered as a trigger for an inflammatory response that could promote adverse pregnancy outcome (APO). We hypothesized that BV-related inflammation could be counterbalanced by anti-inflammatory and mucosal homeostatic responses that could participate in pregnancy outcom...

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Autores principales: Faure, Emmanuel, Faure, Karine, Figeac, Martin, Kipnis, Eric, Grandjean, Teddy, Dubucquoi, Sylvain, Villenet, Céline, Grandbastien, Bruno, Brabant, Gilles, Subtil, Damien, Dessein, Rodrigue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748914/
https://www.ncbi.nlm.nih.gov/pubmed/26844497
http://dx.doi.org/10.1097/MD.0000000000002668
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author Faure, Emmanuel
Faure, Karine
Figeac, Martin
Kipnis, Eric
Grandjean, Teddy
Dubucquoi, Sylvain
Villenet, Céline
Grandbastien, Bruno
Brabant, Gilles
Subtil, Damien
Dessein, Rodrigue
author_facet Faure, Emmanuel
Faure, Karine
Figeac, Martin
Kipnis, Eric
Grandjean, Teddy
Dubucquoi, Sylvain
Villenet, Céline
Grandbastien, Bruno
Brabant, Gilles
Subtil, Damien
Dessein, Rodrigue
author_sort Faure, Emmanuel
collection PubMed
description Bacterial vaginosis (BV) is considered as a trigger for an inflammatory response that could promote adverse pregnancy outcome (APO). We hypothesized that BV-related inflammation could be counterbalanced by anti-inflammatory and mucosal homeostatic responses that could participate in pregnancy outcomes. A total of 402 vaginal self-samples from pregnant women in their first trimester were screened by Nugent score. In this population, we enrolled 23 pregnant women with BV but without APO, 5 pregnant women with BV and developing APO, 21 pregnant women with intermediate flora, and 28 random control samples from pregnant women without BV or APO. BV without APO in pregnant women was associated with 28-fold interleukin-8, 5-fold interleukin-10, and 40-fold interleukin-22 increases in expression compared to controls. BV associated with APO in pregnant women shared 4-fold increase in tumor necrosis factor, 100-fold decrease in interleukin-10, and no variation in interleukin-22 expressions compared to controls. Next-generation sequencing of vaginal microbiota revealed a shift from obligate anaerobic bacteria dominance in BV without APO pregnant women to Lactobacillus dominance microbiota in BV with APO. Our results show that the anti-inflammatory and mucosal homeostatic responses to BV may determine outcome of pregnancy in the setting of BV possibly through effects on the vaginal microbiota.
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spelling pubmed-47489142016-04-01 Vaginal Mucosal Homeostatic Response May Determine Pregnancy Outcome in Women With Bacterial Vaginosis: A Pilot Study Faure, Emmanuel Faure, Karine Figeac, Martin Kipnis, Eric Grandjean, Teddy Dubucquoi, Sylvain Villenet, Céline Grandbastien, Bruno Brabant, Gilles Subtil, Damien Dessein, Rodrigue Medicine (Baltimore) 4600 Bacterial vaginosis (BV) is considered as a trigger for an inflammatory response that could promote adverse pregnancy outcome (APO). We hypothesized that BV-related inflammation could be counterbalanced by anti-inflammatory and mucosal homeostatic responses that could participate in pregnancy outcomes. A total of 402 vaginal self-samples from pregnant women in their first trimester were screened by Nugent score. In this population, we enrolled 23 pregnant women with BV but without APO, 5 pregnant women with BV and developing APO, 21 pregnant women with intermediate flora, and 28 random control samples from pregnant women without BV or APO. BV without APO in pregnant women was associated with 28-fold interleukin-8, 5-fold interleukin-10, and 40-fold interleukin-22 increases in expression compared to controls. BV associated with APO in pregnant women shared 4-fold increase in tumor necrosis factor, 100-fold decrease in interleukin-10, and no variation in interleukin-22 expressions compared to controls. Next-generation sequencing of vaginal microbiota revealed a shift from obligate anaerobic bacteria dominance in BV without APO pregnant women to Lactobacillus dominance microbiota in BV with APO. Our results show that the anti-inflammatory and mucosal homeostatic responses to BV may determine outcome of pregnancy in the setting of BV possibly through effects on the vaginal microbiota. Wolters Kluwer Health 2016-02-08 /pmc/articles/PMC4748914/ /pubmed/26844497 http://dx.doi.org/10.1097/MD.0000000000002668 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4600
Faure, Emmanuel
Faure, Karine
Figeac, Martin
Kipnis, Eric
Grandjean, Teddy
Dubucquoi, Sylvain
Villenet, Céline
Grandbastien, Bruno
Brabant, Gilles
Subtil, Damien
Dessein, Rodrigue
Vaginal Mucosal Homeostatic Response May Determine Pregnancy Outcome in Women With Bacterial Vaginosis: A Pilot Study
title Vaginal Mucosal Homeostatic Response May Determine Pregnancy Outcome in Women With Bacterial Vaginosis: A Pilot Study
title_full Vaginal Mucosal Homeostatic Response May Determine Pregnancy Outcome in Women With Bacterial Vaginosis: A Pilot Study
title_fullStr Vaginal Mucosal Homeostatic Response May Determine Pregnancy Outcome in Women With Bacterial Vaginosis: A Pilot Study
title_full_unstemmed Vaginal Mucosal Homeostatic Response May Determine Pregnancy Outcome in Women With Bacterial Vaginosis: A Pilot Study
title_short Vaginal Mucosal Homeostatic Response May Determine Pregnancy Outcome in Women With Bacterial Vaginosis: A Pilot Study
title_sort vaginal mucosal homeostatic response may determine pregnancy outcome in women with bacterial vaginosis: a pilot study
topic 4600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748914/
https://www.ncbi.nlm.nih.gov/pubmed/26844497
http://dx.doi.org/10.1097/MD.0000000000002668
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