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Haemosporidian Parasites of Antelopes and Other Vertebrates from Gabon, Central Africa

Re-examination, using molecular tools, of the diversity of haemosporidian parasites (among which the agents of human malaria are the best known) has generally led to rearrangements of traditional classifications. In this study, we explored the diversity of haemosporidian parasites infecting vertebra...

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Autores principales: Boundenga, Larson, Makanga, Boris, Ollomo, Benjamin, Gilabert, Aude, Rougeron, Virginie, Mve-Ondo, Bertrand, Arnathau, Céline, Durand, Patrick, Moukodoum, Nancy Diamella, Okouga, Alain-Prince, Delicat-Loembet, Lucresse, Yacka-Mouele, Lauriane, Rahola, Nil, Leroy, Eric, BA, Cheikh Tidiane, Renaud, Francois, Prugnolle, Franck, Paupy, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749209/
https://www.ncbi.nlm.nih.gov/pubmed/26863304
http://dx.doi.org/10.1371/journal.pone.0148958
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author Boundenga, Larson
Makanga, Boris
Ollomo, Benjamin
Gilabert, Aude
Rougeron, Virginie
Mve-Ondo, Bertrand
Arnathau, Céline
Durand, Patrick
Moukodoum, Nancy Diamella
Okouga, Alain-Prince
Delicat-Loembet, Lucresse
Yacka-Mouele, Lauriane
Rahola, Nil
Leroy, Eric
BA, Cheikh Tidiane
Renaud, Francois
Prugnolle, Franck
Paupy, Christophe
author_facet Boundenga, Larson
Makanga, Boris
Ollomo, Benjamin
Gilabert, Aude
Rougeron, Virginie
Mve-Ondo, Bertrand
Arnathau, Céline
Durand, Patrick
Moukodoum, Nancy Diamella
Okouga, Alain-Prince
Delicat-Loembet, Lucresse
Yacka-Mouele, Lauriane
Rahola, Nil
Leroy, Eric
BA, Cheikh Tidiane
Renaud, Francois
Prugnolle, Franck
Paupy, Christophe
author_sort Boundenga, Larson
collection PubMed
description Re-examination, using molecular tools, of the diversity of haemosporidian parasites (among which the agents of human malaria are the best known) has generally led to rearrangements of traditional classifications. In this study, we explored the diversity of haemosporidian parasites infecting vertebrate species (particularly mammals, birds and reptiles) living in the forests of Gabon (Central Africa), by analyzing a collection of 492 bushmeat samples. We found that samples from five mammalian species (four duiker and one pangolin species), one bird and one turtle species were infected by haemosporidian parasites. In duikers (from which most of the infected specimens were obtained), we demonstrated the existence of at least two distinct parasite lineages related to Polychromophilus species (i.e., bat haemosporidian parasites) and to sauropsid Plasmodium (from birds and lizards). Molecular screening of sylvatic mosquitoes captured during a longitudinal survey revealed the presence of these haemosporidian parasite lineages also in several Anopheles species, suggesting a potential role in their transmission. Our results show that, differently from what was previously thought, several independent clades of haemosporidian parasites (family Plasmodiidae) infect mammals and are transmitted by anopheline mosquitoes.
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spelling pubmed-47492092016-02-26 Haemosporidian Parasites of Antelopes and Other Vertebrates from Gabon, Central Africa Boundenga, Larson Makanga, Boris Ollomo, Benjamin Gilabert, Aude Rougeron, Virginie Mve-Ondo, Bertrand Arnathau, Céline Durand, Patrick Moukodoum, Nancy Diamella Okouga, Alain-Prince Delicat-Loembet, Lucresse Yacka-Mouele, Lauriane Rahola, Nil Leroy, Eric BA, Cheikh Tidiane Renaud, Francois Prugnolle, Franck Paupy, Christophe PLoS One Research Article Re-examination, using molecular tools, of the diversity of haemosporidian parasites (among which the agents of human malaria are the best known) has generally led to rearrangements of traditional classifications. In this study, we explored the diversity of haemosporidian parasites infecting vertebrate species (particularly mammals, birds and reptiles) living in the forests of Gabon (Central Africa), by analyzing a collection of 492 bushmeat samples. We found that samples from five mammalian species (four duiker and one pangolin species), one bird and one turtle species were infected by haemosporidian parasites. In duikers (from which most of the infected specimens were obtained), we demonstrated the existence of at least two distinct parasite lineages related to Polychromophilus species (i.e., bat haemosporidian parasites) and to sauropsid Plasmodium (from birds and lizards). Molecular screening of sylvatic mosquitoes captured during a longitudinal survey revealed the presence of these haemosporidian parasite lineages also in several Anopheles species, suggesting a potential role in their transmission. Our results show that, differently from what was previously thought, several independent clades of haemosporidian parasites (family Plasmodiidae) infect mammals and are transmitted by anopheline mosquitoes. Public Library of Science 2016-02-10 /pmc/articles/PMC4749209/ /pubmed/26863304 http://dx.doi.org/10.1371/journal.pone.0148958 Text en © 2016 Boundenga et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Boundenga, Larson
Makanga, Boris
Ollomo, Benjamin
Gilabert, Aude
Rougeron, Virginie
Mve-Ondo, Bertrand
Arnathau, Céline
Durand, Patrick
Moukodoum, Nancy Diamella
Okouga, Alain-Prince
Delicat-Loembet, Lucresse
Yacka-Mouele, Lauriane
Rahola, Nil
Leroy, Eric
BA, Cheikh Tidiane
Renaud, Francois
Prugnolle, Franck
Paupy, Christophe
Haemosporidian Parasites of Antelopes and Other Vertebrates from Gabon, Central Africa
title Haemosporidian Parasites of Antelopes and Other Vertebrates from Gabon, Central Africa
title_full Haemosporidian Parasites of Antelopes and Other Vertebrates from Gabon, Central Africa
title_fullStr Haemosporidian Parasites of Antelopes and Other Vertebrates from Gabon, Central Africa
title_full_unstemmed Haemosporidian Parasites of Antelopes and Other Vertebrates from Gabon, Central Africa
title_short Haemosporidian Parasites of Antelopes and Other Vertebrates from Gabon, Central Africa
title_sort haemosporidian parasites of antelopes and other vertebrates from gabon, central africa
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749209/
https://www.ncbi.nlm.nih.gov/pubmed/26863304
http://dx.doi.org/10.1371/journal.pone.0148958
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