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Protection of Human Pancreatic Islets from Lipotoxicity by Modulation of the Translocon

Type 2 diabetes is characterized by peripheral insulin resistance and pancreatic beta cell dysfunction. Elevated free fatty acids (FFAs) may impair beta cell function and mass (lipotoxicity). Altered calcium homeostasis may be involved in defective insulin release. The endoplasmic reticulum (ER) is...

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Detalles Bibliográficos
Autores principales:	Cassel, R., Ducreux, S., Alam, M. R., Dingreville, F., Berlé, C., Burda-Jacob, K., Chauvin, M. A., Chikh, K., Païta, L., Al-Mawla, R., Crola Da Silva, C., Rieusset, J., Thivolet, C., Van Coppenolle, F., Madec, A. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749224/ https://www.ncbi.nlm.nih.gov/pubmed/26862742 http://dx.doi.org/10.1371/journal.pone.0148686

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