Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells

Mutations of the huntingtin protein (HTT) gene underlie both adult-onset and juvenile forms of Huntington’s disease (HD). HTT modulates mitotic spindle orientation and cell fate in mouse cortical progenitors from the ventricular zone. Using human embryonic stem cells (hESC) characterized as carrying...

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Detalles Bibliográficos
Autores principales: Lopes, Carla, Aubert, Sophie, Bourgois-Rocha, Fany, Barnat, Monia, Rego, Ana Cristina, Déglon, Nicole, Perrier, Anselme L., Humbert, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749329/
https://www.ncbi.nlm.nih.gov/pubmed/26863614
http://dx.doi.org/10.1371/journal.pone.0148680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749329/
https://www.ncbi.nlm.nih.gov/pubmed/26863614
http://dx.doi.org/10.1371/journal.pone.0148680

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