A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

SUMO-modification of nuclear proteins has profound effects on gene expression. However, non-toxic chemical tools that modulate sumoylation in cells are lacking. Here, to identify small molecule sumoylation inhibitors we developed a cell-based screen that focused on the well-sumoylated substrate, hum...

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Detalles Bibliográficos
Autores principales: Suzawa, Miyuki, Miranda, Diego A, Ramos, Karmela A, Ang, Kenny K-H, Faivre, Emily J, Wilson, Christopher G, Caboni, Laura, Arkin, Michelle R, Kim, Yeong-Sang, Fletterick, Robert J, Diaz, Aaron, Schneekloth, John S, Ingraham, Holly A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749390/
https://www.ncbi.nlm.nih.gov/pubmed/26653140
http://dx.doi.org/10.7554/eLife.09003

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