Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest

ABSTRACT: Bioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill. (Cardiopteridaceae) led to the isolation of ethyl esters of three new triterpenoid saponins (1–3) and the known sesquiterpenoid cinnamosmolide (4). The structu...

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Detalles Bibliográficos
Autores principales: Su, Qingxi, Brodie, Peggy J., Liu, Yixi, Miller, James S., Andrianjafy, Naina M., Antsiferana, Rabodo, Rasamison, Vincent E., Kingston, David G. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749521/
https://www.ncbi.nlm.nih.gov/pubmed/26746216
http://dx.doi.org/10.1007/s13659-015-0083-1
Descripción
Sumario:ABSTRACT: Bioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill. (Cardiopteridaceae) led to the isolation of ethyl esters of three new triterpenoid saponins (1–3) and the known sesquiterpenoid cinnamosmolide (4). The structures of 1–3 were elucidated by extensive 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 2, and 4 showed moderate cytotoxicity against the A2780 human ovarian cancer cell line with IC(50) values of 2.8, 10.2 and 2.0 µM, respectively. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-015-0083-1) contains supplementary material, which is available to authorized users.

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