Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest

ABSTRACT: Bioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill. (Cardiopteridaceae) led to the isolation of ethyl esters of three new triterpenoid saponins (1–3) and the known sesquiterpenoid cinnamosmolide (4). The structu...

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Autores principales: Su, Qingxi, Brodie, Peggy J., Liu, Yixi, Miller, James S., Andrianjafy, Naina M., Antsiferana, Rabodo, Rasamison, Vincent E., Kingston, David G. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749521/
https://www.ncbi.nlm.nih.gov/pubmed/26746216
http://dx.doi.org/10.1007/s13659-015-0083-1
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author Su, Qingxi
Brodie, Peggy J.
Liu, Yixi
Miller, James S.
Andrianjafy, Naina M.
Antsiferana, Rabodo
Rasamison, Vincent E.
Kingston, David G. I.
author_facet Su, Qingxi
Brodie, Peggy J.
Liu, Yixi
Miller, James S.
Andrianjafy, Naina M.
Antsiferana, Rabodo
Rasamison, Vincent E.
Kingston, David G. I.
author_sort Su, Qingxi
collection PubMed
description ABSTRACT: Bioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill. (Cardiopteridaceae) led to the isolation of ethyl esters of three new triterpenoid saponins (1–3) and the known sesquiterpenoid cinnamosmolide (4). The structures of 1–3 were elucidated by extensive 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 2, and 4 showed moderate cytotoxicity against the A2780 human ovarian cancer cell line with IC(50) values of 2.8, 10.2 and 2.0 µM, respectively. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-015-0083-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-47495212016-02-19 Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest Su, Qingxi Brodie, Peggy J. Liu, Yixi Miller, James S. Andrianjafy, Naina M. Antsiferana, Rabodo Rasamison, Vincent E. Kingston, David G. I. Nat Prod Bioprospect Original Article ABSTRACT: Bioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill. (Cardiopteridaceae) led to the isolation of ethyl esters of three new triterpenoid saponins (1–3) and the known sesquiterpenoid cinnamosmolide (4). The structures of 1–3 were elucidated by extensive 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 2, and 4 showed moderate cytotoxicity against the A2780 human ovarian cancer cell line with IC(50) values of 2.8, 10.2 and 2.0 µM, respectively. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-015-0083-1) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2016-01-08 /pmc/articles/PMC4749521/ /pubmed/26746216 http://dx.doi.org/10.1007/s13659-015-0083-1 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Su, Qingxi
Brodie, Peggy J.
Liu, Yixi
Miller, James S.
Andrianjafy, Naina M.
Antsiferana, Rabodo
Rasamison, Vincent E.
Kingston, David G. I.
Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest
title Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest
title_full Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest
title_fullStr Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest
title_full_unstemmed Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest
title_short Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest
title_sort antiproliferative triterpenoid saponins from leptaulus citroides baill. from the madagascar rain forest
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749521/
https://www.ncbi.nlm.nih.gov/pubmed/26746216
http://dx.doi.org/10.1007/s13659-015-0083-1
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