The Use of a Combination of RDC and Chiroptical Spectroscopy for Determination of the Absolute Configuration of Fusariumin A from the Fungus Fusarium sp.

A new alkylpyrrole derivative, fusariumin A (1), was isolated from the culture broth of the fungus Fusarium sp. The absolute configuration of fuasiumin A has been established as (2′R,3′R) using a combination of RDC (residual dipolar coupling)-based NMR and DFT-supported chiroptical spectroscopy. It...

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Detalles Bibliográficos
Autores principales: Liu, Liang-Yan, Sun, Han, Griesinger, Christian, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749523/
https://www.ncbi.nlm.nih.gov/pubmed/26791752
http://dx.doi.org/10.1007/s13659-015-0084-0
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author Liu, Liang-Yan
Sun, Han
Griesinger, Christian
Liu, Ji-Kai
author_facet Liu, Liang-Yan
Sun, Han
Griesinger, Christian
Liu, Ji-Kai
author_sort Liu, Liang-Yan
collection PubMed
description A new alkylpyrrole derivative, fusariumin A (1), was isolated from the culture broth of the fungus Fusarium sp. The absolute configuration of fuasiumin A has been established as (2′R,3′R) using a combination of RDC (residual dipolar coupling)-based NMR and DFT-supported chiroptical spectroscopy. It is worth to note that in this study without the aid of the RDC analysis, an unambiguous determination of configuration and conformation was not feasible due to the excessive conformational possibilities of this open-chain compound. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-015-0084-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-47495232016-02-19 The Use of a Combination of RDC and Chiroptical Spectroscopy for Determination of the Absolute Configuration of Fusariumin A from the Fungus Fusarium sp. Liu, Liang-Yan Sun, Han Griesinger, Christian Liu, Ji-Kai Nat Prod Bioprospect Original Article A new alkylpyrrole derivative, fusariumin A (1), was isolated from the culture broth of the fungus Fusarium sp. The absolute configuration of fuasiumin A has been established as (2′R,3′R) using a combination of RDC (residual dipolar coupling)-based NMR and DFT-supported chiroptical spectroscopy. It is worth to note that in this study without the aid of the RDC analysis, an unambiguous determination of configuration and conformation was not feasible due to the excessive conformational possibilities of this open-chain compound. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-015-0084-0) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2016-01-20 /pmc/articles/PMC4749523/ /pubmed/26791752 http://dx.doi.org/10.1007/s13659-015-0084-0 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Liu, Liang-Yan
Sun, Han
Griesinger, Christian
Liu, Ji-Kai
The Use of a Combination of RDC and Chiroptical Spectroscopy for Determination of the Absolute Configuration of Fusariumin A from the Fungus Fusarium sp.
title The Use of a Combination of RDC and Chiroptical Spectroscopy for Determination of the Absolute Configuration of Fusariumin A from the Fungus Fusarium sp.
title_full The Use of a Combination of RDC and Chiroptical Spectroscopy for Determination of the Absolute Configuration of Fusariumin A from the Fungus Fusarium sp.
title_fullStr The Use of a Combination of RDC and Chiroptical Spectroscopy for Determination of the Absolute Configuration of Fusariumin A from the Fungus Fusarium sp.
title_full_unstemmed The Use of a Combination of RDC and Chiroptical Spectroscopy for Determination of the Absolute Configuration of Fusariumin A from the Fungus Fusarium sp.
title_short The Use of a Combination of RDC and Chiroptical Spectroscopy for Determination of the Absolute Configuration of Fusariumin A from the Fungus Fusarium sp.
title_sort use of a combination of rdc and chiroptical spectroscopy for determination of the absolute configuration of fusariumin a from the fungus fusarium sp.
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749523/
https://www.ncbi.nlm.nih.gov/pubmed/26791752
http://dx.doi.org/10.1007/s13659-015-0084-0
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