Koninginins N-Q, Polyketides from the Endophytic Fungus Trichoderma koningiopsis Harbored in Panax notoginseng

ABSTRACT: Four new fungal polyketides named koninginins N-Q (1–4), together with four known analogues (5–8), were isolated from the endophytic fungus Trichoderma koningiopsis YIM PH30002 harbored in Panax notoginseng. Their structures were determined on the basis of spectral data interpretation. The...

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Detalles Bibliográficos
Autores principales: Liu, Kai, Yang, Ya-Bin, Chen, Jin-Lian, Miao, Cui-Ping, Wang, Qiang, Zhou, Hao, Chen, You-Wei, Li, Yi-Qing, Ding, Zhong-Tao, Zhao, Li-Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749524/
https://www.ncbi.nlm.nih.gov/pubmed/26753920
http://dx.doi.org/10.1007/s13659-015-0085-z
Descripción
Sumario:ABSTRACT: Four new fungal polyketides named koninginins N-Q (1–4), together with four known analogues (5–8), were isolated from the endophytic fungus Trichoderma koningiopsis YIM PH30002 harbored in Panax notoginseng. Their structures were determined on the basis of spectral data interpretation. These compounds were evaluated for their antifungal activity, nitric oxide inhibition, and anticoagulant activity. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13659-015-0085-z) contains supplementary material, which is available to authorized users.

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