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Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition

The 26S proteasome is responsible for the selective, ATP-dependent degradation of polyubiquitinated cellular proteins. Removal of ubiquitin chains from targeted substrates at the proteasome is a prerequisite for substrate processing and is accomplished by Rpn11, a deubiquitinase within the ‘lid’ sub...

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Detalles Bibliográficos
Autores principales:	Dambacher, Corey M, Worden, Evan J, Herzik, Mark A, Martin, Andreas, Lander, Gabriel C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749569/ https://www.ncbi.nlm.nih.gov/pubmed/26744777 http://dx.doi.org/10.7554/eLife.13027

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