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Sample Size Reassessment and Hypothesis Testing in Adaptive Survival Trials
Mid-study design modifications are becoming increasingly accepted in confirmatory clinical trials, so long as appropriate methods are applied such that error rates are controlled. It is therefore unfortunate that the important case of time-to-event endpoints is not easily handled by the standard the...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749572/ https://www.ncbi.nlm.nih.gov/pubmed/26863139 http://dx.doi.org/10.1371/journal.pone.0146465 |