The cannabinoid system in the retrosplenial cortex modulates fear memory consolidation, reconsolidation, and extinction

Despite the fact that the cannabinoid receptor type 1 (CB1R) plays a pivotal role in emotional memory processing in different regions of the brain, its function in the retrosplenial cortex (RSC) remains unknown. Here, using contextual fear conditioning in rats, we showed that a post-training intra-R...

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Autores principales: Sachser, Ricardo Marcelo, Crestani, Ana Paula, Quillfeldt, Jorge Alberto, Mello e Souza, Tadeu, de Oliveira Alvares, Lucas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749733/
https://www.ncbi.nlm.nih.gov/pubmed/26572648
http://dx.doi.org/10.1101/lm.039891.115
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author Sachser, Ricardo Marcelo
Crestani, Ana Paula
Quillfeldt, Jorge Alberto
Mello e Souza, Tadeu
de Oliveira Alvares, Lucas
author_facet Sachser, Ricardo Marcelo
Crestani, Ana Paula
Quillfeldt, Jorge Alberto
Mello e Souza, Tadeu
de Oliveira Alvares, Lucas
author_sort Sachser, Ricardo Marcelo
collection PubMed
description Despite the fact that the cannabinoid receptor type 1 (CB1R) plays a pivotal role in emotional memory processing in different regions of the brain, its function in the retrosplenial cortex (RSC) remains unknown. Here, using contextual fear conditioning in rats, we showed that a post-training intra-RSC infusion of the CB1R antagonist AM251 impaired, and the agonist CP55940 improved, long-term memory consolidation. Additionally, a post-reactivation infusion of AM251 enhanced memory reconsolidation, while CP55940 had the opposite effect. Finally, AM251 blocked extinction, whereas CP55940 facilitated it and maintained memory extinguished over time. Altogether, our data strongly suggest that the cannabinoid system of the RSC modulates emotional memory.
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spelling pubmed-47497332016-12-01 The cannabinoid system in the retrosplenial cortex modulates fear memory consolidation, reconsolidation, and extinction Sachser, Ricardo Marcelo Crestani, Ana Paula Quillfeldt, Jorge Alberto Mello e Souza, Tadeu de Oliveira Alvares, Lucas Learn Mem Brief Communication Despite the fact that the cannabinoid receptor type 1 (CB1R) plays a pivotal role in emotional memory processing in different regions of the brain, its function in the retrosplenial cortex (RSC) remains unknown. Here, using contextual fear conditioning in rats, we showed that a post-training intra-RSC infusion of the CB1R antagonist AM251 impaired, and the agonist CP55940 improved, long-term memory consolidation. Additionally, a post-reactivation infusion of AM251 enhanced memory reconsolidation, while CP55940 had the opposite effect. Finally, AM251 blocked extinction, whereas CP55940 facilitated it and maintained memory extinguished over time. Altogether, our data strongly suggest that the cannabinoid system of the RSC modulates emotional memory. Cold Spring Harbor Laboratory Press 2015-12 /pmc/articles/PMC4749733/ /pubmed/26572648 http://dx.doi.org/10.1101/lm.039891.115 Text en © 2015 Sachser et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Brief Communication
Sachser, Ricardo Marcelo
Crestani, Ana Paula
Quillfeldt, Jorge Alberto
Mello e Souza, Tadeu
de Oliveira Alvares, Lucas
The cannabinoid system in the retrosplenial cortex modulates fear memory consolidation, reconsolidation, and extinction
title The cannabinoid system in the retrosplenial cortex modulates fear memory consolidation, reconsolidation, and extinction
title_full The cannabinoid system in the retrosplenial cortex modulates fear memory consolidation, reconsolidation, and extinction
title_fullStr The cannabinoid system in the retrosplenial cortex modulates fear memory consolidation, reconsolidation, and extinction
title_full_unstemmed The cannabinoid system in the retrosplenial cortex modulates fear memory consolidation, reconsolidation, and extinction
title_short The cannabinoid system in the retrosplenial cortex modulates fear memory consolidation, reconsolidation, and extinction
title_sort cannabinoid system in the retrosplenial cortex modulates fear memory consolidation, reconsolidation, and extinction
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749733/
https://www.ncbi.nlm.nih.gov/pubmed/26572648
http://dx.doi.org/10.1101/lm.039891.115
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