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Identification of genes related to learning and memory in the brain transcriptome of the mollusc, Hermissenda crassicornis

The sea slug Hermissenda crassicornis (Mollusca, Gastropoda, Nudibranchia) has been studied extensively in associative learning paradigms. However, lack of genetic information previously hindered molecular-level investigations. Here, the Hermissenda brain transcriptome was sequenced and assembled de...

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Autores principales: Tamvacakis, Arianna N., Senatore, Adriano, Katz, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749734/
https://www.ncbi.nlm.nih.gov/pubmed/26572652
http://dx.doi.org/10.1101/lm.038158.115
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author Tamvacakis, Arianna N.
Senatore, Adriano
Katz, Paul S.
author_facet Tamvacakis, Arianna N.
Senatore, Adriano
Katz, Paul S.
author_sort Tamvacakis, Arianna N.
collection PubMed
description The sea slug Hermissenda crassicornis (Mollusca, Gastropoda, Nudibranchia) has been studied extensively in associative learning paradigms. However, lack of genetic information previously hindered molecular-level investigations. Here, the Hermissenda brain transcriptome was sequenced and assembled de novo, producing 165,743 total transcripts. Orthologs of 95 genes implicated in learning were identified. These included genes for a serotonin receptor and a GABA-B receptor subunit that had not been previously described in molluscs, as well as an adenylyl cyclase gene not previously described in gastropods. This study illustrates the Hermissenda transcriptome's potential as an important genetic tool in future learning and memory research.
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spelling pubmed-47497342016-12-01 Identification of genes related to learning and memory in the brain transcriptome of the mollusc, Hermissenda crassicornis Tamvacakis, Arianna N. Senatore, Adriano Katz, Paul S. Learn Mem Brief Communication The sea slug Hermissenda crassicornis (Mollusca, Gastropoda, Nudibranchia) has been studied extensively in associative learning paradigms. However, lack of genetic information previously hindered molecular-level investigations. Here, the Hermissenda brain transcriptome was sequenced and assembled de novo, producing 165,743 total transcripts. Orthologs of 95 genes implicated in learning were identified. These included genes for a serotonin receptor and a GABA-B receptor subunit that had not been previously described in molluscs, as well as an adenylyl cyclase gene not previously described in gastropods. This study illustrates the Hermissenda transcriptome's potential as an important genetic tool in future learning and memory research. Cold Spring Harbor Laboratory Press 2015-12 /pmc/articles/PMC4749734/ /pubmed/26572652 http://dx.doi.org/10.1101/lm.038158.115 Text en © 2015 Tamvacakis et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Brief Communication
Tamvacakis, Arianna N.
Senatore, Adriano
Katz, Paul S.
Identification of genes related to learning and memory in the brain transcriptome of the mollusc, Hermissenda crassicornis
title Identification of genes related to learning and memory in the brain transcriptome of the mollusc, Hermissenda crassicornis
title_full Identification of genes related to learning and memory in the brain transcriptome of the mollusc, Hermissenda crassicornis
title_fullStr Identification of genes related to learning and memory in the brain transcriptome of the mollusc, Hermissenda crassicornis
title_full_unstemmed Identification of genes related to learning and memory in the brain transcriptome of the mollusc, Hermissenda crassicornis
title_short Identification of genes related to learning and memory in the brain transcriptome of the mollusc, Hermissenda crassicornis
title_sort identification of genes related to learning and memory in the brain transcriptome of the mollusc, hermissenda crassicornis
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749734/
https://www.ncbi.nlm.nih.gov/pubmed/26572652
http://dx.doi.org/10.1101/lm.038158.115
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