Optimization of visual training for full recovery from severe amblyopia in adults

The severe amblyopia induced by chronic monocular deprivation is highly resistant to reversal in adulthood. Here we use a rodent model to show that recovery from deprivation amblyopia can be achieved in adults by a two-step sequence, involving enhancement of synaptic plasticity in the visual cortex...

Descripción completa

Detalles Bibliográficos
Autores principales: Eaton, Nicolette C., Sheehan, Hanna Marie, Quinlan, Elizabeth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749829/
https://www.ncbi.nlm.nih.gov/pubmed/26787781
http://dx.doi.org/10.1101/lm.040295.115
_version_ 1782415329902723072
author Eaton, Nicolette C.
Sheehan, Hanna Marie
Quinlan, Elizabeth M.
author_facet Eaton, Nicolette C.
Sheehan, Hanna Marie
Quinlan, Elizabeth M.
author_sort Eaton, Nicolette C.
collection PubMed
description The severe amblyopia induced by chronic monocular deprivation is highly resistant to reversal in adulthood. Here we use a rodent model to show that recovery from deprivation amblyopia can be achieved in adults by a two-step sequence, involving enhancement of synaptic plasticity in the visual cortex by dark exposure followed immediately by visual training. The perceptual learning induced by visual training contributes to the recovery of vision and can be optimized to drive full recovery of visual acuity in severely amblyopic adults.
format Online
Article
Text
id pubmed-4749829
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Cold Spring Harbor Laboratory Press
record_format MEDLINE/PubMed
spelling pubmed-47498292017-02-01 Optimization of visual training for full recovery from severe amblyopia in adults Eaton, Nicolette C. Sheehan, Hanna Marie Quinlan, Elizabeth M. Learn Mem Brief Communication The severe amblyopia induced by chronic monocular deprivation is highly resistant to reversal in adulthood. Here we use a rodent model to show that recovery from deprivation amblyopia can be achieved in adults by a two-step sequence, involving enhancement of synaptic plasticity in the visual cortex by dark exposure followed immediately by visual training. The perceptual learning induced by visual training contributes to the recovery of vision and can be optimized to drive full recovery of visual acuity in severely amblyopic adults. Cold Spring Harbor Laboratory Press 2016-02 /pmc/articles/PMC4749829/ /pubmed/26787781 http://dx.doi.org/10.1101/lm.040295.115 Text en © 2016 Eaton et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Brief Communication
Eaton, Nicolette C.
Sheehan, Hanna Marie
Quinlan, Elizabeth M.
Optimization of visual training for full recovery from severe amblyopia in adults
title Optimization of visual training for full recovery from severe amblyopia in adults
title_full Optimization of visual training for full recovery from severe amblyopia in adults
title_fullStr Optimization of visual training for full recovery from severe amblyopia in adults
title_full_unstemmed Optimization of visual training for full recovery from severe amblyopia in adults
title_short Optimization of visual training for full recovery from severe amblyopia in adults
title_sort optimization of visual training for full recovery from severe amblyopia in adults
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749829/
https://www.ncbi.nlm.nih.gov/pubmed/26787781
http://dx.doi.org/10.1101/lm.040295.115
work_keys_str_mv AT eatonnicolettec optimizationofvisualtrainingforfullrecoveryfromsevereamblyopiainadults
AT sheehanhannamarie optimizationofvisualtrainingforfullrecoveryfromsevereamblyopiainadults
AT quinlanelizabethm optimizationofvisualtrainingforfullrecoveryfromsevereamblyopiainadults

Ejemplares similares