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Lamotrigine as monotherapy in clinical practice: efficacy of various dosages in epilepsy

OBJECTIVES/AIMS: The study was designed to evaluate the optimal dosage of lamotrigine, as monotherapy, in the treatment of adults suffering from complex partial seizures with or without secondary generalization in everyday clinical practice. MATERIALS AND METHODS: The ones used in this study was the...

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Autores principales: Warshavsky, Anton, Eilam, Anda, Gilad, Ronit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749880/
https://www.ncbi.nlm.nih.gov/pubmed/26904382
http://dx.doi.org/10.1002/brb3.419
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author Warshavsky, Anton
Eilam, Anda
Gilad, Ronit
author_facet Warshavsky, Anton
Eilam, Anda
Gilad, Ronit
author_sort Warshavsky, Anton
collection PubMed
description OBJECTIVES/AIMS: The study was designed to evaluate the optimal dosage of lamotrigine, as monotherapy, in the treatment of adults suffering from complex partial seizures with or without secondary generalization in everyday clinical practice. MATERIALS AND METHODS: The ones used in this study was the collection of the data of all adult patients treated with lamotrigine, retrospectively. The dosage and efficacy of treatment were evaluated along with side effects and retention rate. RESULTS: They showed that, out of 188 patients, 77% continued lamotrigine treatment; the mean effective dose was 250 mg or higher of lamotrigine, and the results more pronounced in older patients (age above 30 years) and those with a longer disease duration (5 years and more). CONCLUSION: It may be appropriate to reach a daily lamotrigine dose above 250 mg in adult patients suffering from epilepsy for more than 5 years using lamotrigine as monotherapy.
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spelling pubmed-47498802016-02-22 Lamotrigine as monotherapy in clinical practice: efficacy of various dosages in epilepsy Warshavsky, Anton Eilam, Anda Gilad, Ronit Brain Behav Original Research OBJECTIVES/AIMS: The study was designed to evaluate the optimal dosage of lamotrigine, as monotherapy, in the treatment of adults suffering from complex partial seizures with or without secondary generalization in everyday clinical practice. MATERIALS AND METHODS: The ones used in this study was the collection of the data of all adult patients treated with lamotrigine, retrospectively. The dosage and efficacy of treatment were evaluated along with side effects and retention rate. RESULTS: They showed that, out of 188 patients, 77% continued lamotrigine treatment; the mean effective dose was 250 mg or higher of lamotrigine, and the results more pronounced in older patients (age above 30 years) and those with a longer disease duration (5 years and more). CONCLUSION: It may be appropriate to reach a daily lamotrigine dose above 250 mg in adult patients suffering from epilepsy for more than 5 years using lamotrigine as monotherapy. John Wiley and Sons Inc. 2016-02-10 /pmc/articles/PMC4749880/ /pubmed/26904382 http://dx.doi.org/10.1002/brb3.419 Text en © 2016 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Warshavsky, Anton
Eilam, Anda
Gilad, Ronit
Lamotrigine as monotherapy in clinical practice: efficacy of various dosages in epilepsy
title Lamotrigine as monotherapy in clinical practice: efficacy of various dosages in epilepsy
title_full Lamotrigine as monotherapy in clinical practice: efficacy of various dosages in epilepsy
title_fullStr Lamotrigine as monotherapy in clinical practice: efficacy of various dosages in epilepsy
title_full_unstemmed Lamotrigine as monotherapy in clinical practice: efficacy of various dosages in epilepsy
title_short Lamotrigine as monotherapy in clinical practice: efficacy of various dosages in epilepsy
title_sort lamotrigine as monotherapy in clinical practice: efficacy of various dosages in epilepsy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749880/
https://www.ncbi.nlm.nih.gov/pubmed/26904382
http://dx.doi.org/10.1002/brb3.419
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