A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells

Bioinformatics and computational modelling are expected to offer innovative approaches in human medical science. In the present study, we performed computational analyses and made predictions using transcriptome and metabolome datasets obtained from fluorescence-based visualisations of chemotherapy-...

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Autores principales: Koseki, Jun, Matsui, Hidetoshi, Konno, Masamitsu, Nishida, Naohiro, Kawamoto, Koichi, Kano, Yoshihiro, Mori, Masaki, Doki, Yuichiro, Ishii, Hideshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749963/
https://www.ncbi.nlm.nih.gov/pubmed/26864636
http://dx.doi.org/10.1038/srep20726
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author Koseki, Jun
Matsui, Hidetoshi
Konno, Masamitsu
Nishida, Naohiro
Kawamoto, Koichi
Kano, Yoshihiro
Mori, Masaki
Doki, Yuichiro
Ishii, Hideshi
author_facet Koseki, Jun
Matsui, Hidetoshi
Konno, Masamitsu
Nishida, Naohiro
Kawamoto, Koichi
Kano, Yoshihiro
Mori, Masaki
Doki, Yuichiro
Ishii, Hideshi
author_sort Koseki, Jun
collection PubMed
description Bioinformatics and computational modelling are expected to offer innovative approaches in human medical science. In the present study, we performed computational analyses and made predictions using transcriptome and metabolome datasets obtained from fluorescence-based visualisations of chemotherapy-resistant cancer stem cells (CSCs) in the human oesophagus. This approach revealed an uncharacterized role for the ornithine metabolic pathway in the survival of chemotherapy-resistant CSCs. The present study fastens this rationale for further characterisation that may lead to the discovery of innovative drugs against robust CSCs.
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spelling pubmed-47499632016-02-17 A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells Koseki, Jun Matsui, Hidetoshi Konno, Masamitsu Nishida, Naohiro Kawamoto, Koichi Kano, Yoshihiro Mori, Masaki Doki, Yuichiro Ishii, Hideshi Sci Rep Article Bioinformatics and computational modelling are expected to offer innovative approaches in human medical science. In the present study, we performed computational analyses and made predictions using transcriptome and metabolome datasets obtained from fluorescence-based visualisations of chemotherapy-resistant cancer stem cells (CSCs) in the human oesophagus. This approach revealed an uncharacterized role for the ornithine metabolic pathway in the survival of chemotherapy-resistant CSCs. The present study fastens this rationale for further characterisation that may lead to the discovery of innovative drugs against robust CSCs. Nature Publishing Group 2016-02-11 /pmc/articles/PMC4749963/ /pubmed/26864636 http://dx.doi.org/10.1038/srep20726 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Koseki, Jun
Matsui, Hidetoshi
Konno, Masamitsu
Nishida, Naohiro
Kawamoto, Koichi
Kano, Yoshihiro
Mori, Masaki
Doki, Yuichiro
Ishii, Hideshi
A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells
title A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells
title_full A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells
title_fullStr A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells
title_full_unstemmed A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells
title_short A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells
title_sort trans-omics mathematical analysis reveals novel functions of the ornithine metabolic pathway in cancer stem cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749963/
https://www.ncbi.nlm.nih.gov/pubmed/26864636
http://dx.doi.org/10.1038/srep20726
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