Analyzing the Release of Copeptin from the Heart in Acute Myocardial Infarction Using a Transcoronary Gradient Model

Copeptin is the C-terminal end of pre-provasopressin released equimolar to vasopressin into circulation and recently discussed as promising cardiovascular biomarker amendatory to established markers such as troponins. Vasopressin is a cytokine synthesized in the hypothalamus. A direct release of cop...

Descripción completa

Detalles Bibliográficos
Autores principales: Boeckel, Jes-Niels, Oppermann, Jana, Anadol, Remzi, Fichtlscherer, Stephan, Zeiher, Andreas M., Keller, Till
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749978/
https://www.ncbi.nlm.nih.gov/pubmed/26864512
http://dx.doi.org/10.1038/srep20812
_version_ 1782415352852905984
author Boeckel, Jes-Niels
Oppermann, Jana
Anadol, Remzi
Fichtlscherer, Stephan
Zeiher, Andreas M.
Keller, Till
author_facet Boeckel, Jes-Niels
Oppermann, Jana
Anadol, Remzi
Fichtlscherer, Stephan
Zeiher, Andreas M.
Keller, Till
author_sort Boeckel, Jes-Niels
collection PubMed
description Copeptin is the C-terminal end of pre-provasopressin released equimolar to vasopressin into circulation and recently discussed as promising cardiovascular biomarker amendatory to established markers such as troponins. Vasopressin is a cytokine synthesized in the hypothalamus. A direct release of copeptin from the heart into the circulation is implied by data from a rat model showing a cardiac origin in hearts put under cardiovascular wall stress. Therefore, evaluation of a potential release of copeptin from the human heart in acute myocardial infarction (AMI) has been done.
format Online
Article
Text
id pubmed-4749978
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-47499782016-02-18 Analyzing the Release of Copeptin from the Heart in Acute Myocardial Infarction Using a Transcoronary Gradient Model Boeckel, Jes-Niels Oppermann, Jana Anadol, Remzi Fichtlscherer, Stephan Zeiher, Andreas M. Keller, Till Sci Rep Article Copeptin is the C-terminal end of pre-provasopressin released equimolar to vasopressin into circulation and recently discussed as promising cardiovascular biomarker amendatory to established markers such as troponins. Vasopressin is a cytokine synthesized in the hypothalamus. A direct release of copeptin from the heart into the circulation is implied by data from a rat model showing a cardiac origin in hearts put under cardiovascular wall stress. Therefore, evaluation of a potential release of copeptin from the human heart in acute myocardial infarction (AMI) has been done. Nature Publishing Group 2016-02-11 /pmc/articles/PMC4749978/ /pubmed/26864512 http://dx.doi.org/10.1038/srep20812 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Boeckel, Jes-Niels
Oppermann, Jana
Anadol, Remzi
Fichtlscherer, Stephan
Zeiher, Andreas M.
Keller, Till
Analyzing the Release of Copeptin from the Heart in Acute Myocardial Infarction Using a Transcoronary Gradient Model
title Analyzing the Release of Copeptin from the Heart in Acute Myocardial Infarction Using a Transcoronary Gradient Model
title_full Analyzing the Release of Copeptin from the Heart in Acute Myocardial Infarction Using a Transcoronary Gradient Model
title_fullStr Analyzing the Release of Copeptin from the Heart in Acute Myocardial Infarction Using a Transcoronary Gradient Model
title_full_unstemmed Analyzing the Release of Copeptin from the Heart in Acute Myocardial Infarction Using a Transcoronary Gradient Model
title_short Analyzing the Release of Copeptin from the Heart in Acute Myocardial Infarction Using a Transcoronary Gradient Model
title_sort analyzing the release of copeptin from the heart in acute myocardial infarction using a transcoronary gradient model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749978/
https://www.ncbi.nlm.nih.gov/pubmed/26864512
http://dx.doi.org/10.1038/srep20812
work_keys_str_mv AT boeckeljesniels analyzingthereleaseofcopeptinfromtheheartinacutemyocardialinfarctionusingatranscoronarygradientmodel
AT oppermannjana analyzingthereleaseofcopeptinfromtheheartinacutemyocardialinfarctionusingatranscoronarygradientmodel
AT anadolremzi analyzingthereleaseofcopeptinfromtheheartinacutemyocardialinfarctionusingatranscoronarygradientmodel
AT fichtlschererstephan analyzingthereleaseofcopeptinfromtheheartinacutemyocardialinfarctionusingatranscoronarygradientmodel
AT zeiherandreasm analyzingthereleaseofcopeptinfromtheheartinacutemyocardialinfarctionusingatranscoronarygradientmodel
AT kellertill analyzingthereleaseofcopeptinfromtheheartinacutemyocardialinfarctionusingatranscoronarygradientmodel

Ejemplares similares