DOPA-sparing strategy in the treatment of young onset Parkinson's disease

CONTEXT: Late onset Parkinson's disease (LOPD) is a neurodegenerative disorder afflicting individuals of ages 60 and older. However, 5–10% of cases can begin earlier between the ages 20 to 40, and are classified as young onset Parkinson disease (YOPD). AIM: In turn, this study aims to observe t...

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Detalles Bibliográficos
Autores principales: Rana, Abdul Qayyum, Saleh, Mohamad, Yousuf, Muhammad Saad, Mansoor, Wasim, Hussaini, Syed, Rahman, Maniza, Iqbal, Zohair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750343/
https://www.ncbi.nlm.nih.gov/pubmed/26933347
http://dx.doi.org/10.4103/0976-3147.172155
Descripción
Sumario:CONTEXT: Late onset Parkinson's disease (LOPD) is a neurodegenerative disorder afflicting individuals of ages 60 and older. However, 5–10% of cases can begin earlier between the ages 20 to 40, and are classified as young onset Parkinson disease (YOPD). AIM: In turn, this study aims to observe the trend in the choice of drug administered to patients with both YOPD and LOPD, with particular emphasis on this trend in its relation to the practice background of the neurologist. SETTINGS AND DESIGN: A cross-sectional study was conducted in a community based Parkinson's disease and movement disorder clinic. STATISTICAL ANALYSIS USED: Using a retrospective chart review data was obtained and analysed. RESULTS: The results showed that 83% of general neurologists prescribed levodopa to their patients with YOPD, whereas movement-disorder specialists took a different approach altogether. They opted not to use levodopa and, in its stead, prescribed a mixture of alternate drugs.

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