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Bonafide, type-specific human papillomavirus persistence among HIV-positive pregnant women: predictive value for cytological abnormalities, a longitudinal cohort study

This study investigated the rate of human papillomavirus (HPV) persistence, associated risk factors, and predictors of cytological alteration outcomes in a cohort of human immunodeficiency virus-infected pregnant women over an 18-month period. HPV was typed through L1 gene sequencing in cervical sme...

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Autores principales: Meyrelles, Angela RI, Siqueira, Juliana D, dos Santos, Pâmela P, Hofer, Cristina B, Luiz, Ronir R, Seuánez, Héctor N, Almeida, Gutemberg, Soares, Marcelo A, Soares, Esmeralda A, Machado, Elizabeth S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750452/
https://www.ncbi.nlm.nih.gov/pubmed/26872340
http://dx.doi.org/10.1590/0074-02760150393
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author Meyrelles, Angela RI
Siqueira, Juliana D
dos Santos, Pâmela P
Hofer, Cristina B
Luiz, Ronir R
Seuánez, Héctor N
Almeida, Gutemberg
Soares, Marcelo A
Soares, Esmeralda A
Machado, Elizabeth S
author_facet Meyrelles, Angela RI
Siqueira, Juliana D
dos Santos, Pâmela P
Hofer, Cristina B
Luiz, Ronir R
Seuánez, Héctor N
Almeida, Gutemberg
Soares, Marcelo A
Soares, Esmeralda A
Machado, Elizabeth S
author_sort Meyrelles, Angela RI
collection PubMed
description This study investigated the rate of human papillomavirus (HPV) persistence, associated risk factors, and predictors of cytological alteration outcomes in a cohort of human immunodeficiency virus-infected pregnant women over an 18-month period. HPV was typed through L1 gene sequencing in cervical smears collected during gestation and at 12 months after delivery. Outcomes were defined as nonpersistence (clearance of the HPV in the 2nd sample), re-infection (detection of different types of HPV in the 2 samples), and type-specific HPV persistence (the same HPV type found in both samples). An unfavourable cytological outcome was considered when the second exam showed progression to squamous intraepithelial lesion or high squamous intraepithelial lesion. Ninety patients were studied. HPV DNA persistence occurred in 50% of the cases composed of type-specific persistence (30%) or re-infection (20%). A low CD4(+)T-cell count at entry was a risk factor for type-specific, re-infection, or HPV DNA persistence. The odds ratio (OR) was almost three times higher in the type-specific group when compared with the re-infection group (OR = 2.8; 95% confidence interval: 0.43-22.79). Our findings show that bonafide (type-specific) HPV persistence is a stronger predictor for the development of cytological abnormalities, highlighting the need for HPV typing as opposed to HPV DNA testing in the clinical setting.
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spelling pubmed-47504522016-02-11 Bonafide, type-specific human papillomavirus persistence among HIV-positive pregnant women: predictive value for cytological abnormalities, a longitudinal cohort study Meyrelles, Angela RI Siqueira, Juliana D dos Santos, Pâmela P Hofer, Cristina B Luiz, Ronir R Seuánez, Héctor N Almeida, Gutemberg Soares, Marcelo A Soares, Esmeralda A Machado, Elizabeth S Mem Inst Oswaldo Cruz Articles This study investigated the rate of human papillomavirus (HPV) persistence, associated risk factors, and predictors of cytological alteration outcomes in a cohort of human immunodeficiency virus-infected pregnant women over an 18-month period. HPV was typed through L1 gene sequencing in cervical smears collected during gestation and at 12 months after delivery. Outcomes were defined as nonpersistence (clearance of the HPV in the 2nd sample), re-infection (detection of different types of HPV in the 2 samples), and type-specific HPV persistence (the same HPV type found in both samples). An unfavourable cytological outcome was considered when the second exam showed progression to squamous intraepithelial lesion or high squamous intraepithelial lesion. Ninety patients were studied. HPV DNA persistence occurred in 50% of the cases composed of type-specific persistence (30%) or re-infection (20%). A low CD4(+)T-cell count at entry was a risk factor for type-specific, re-infection, or HPV DNA persistence. The odds ratio (OR) was almost three times higher in the type-specific group when compared with the re-infection group (OR = 2.8; 95% confidence interval: 0.43-22.79). Our findings show that bonafide (type-specific) HPV persistence is a stronger predictor for the development of cytological abnormalities, highlighting the need for HPV typing as opposed to HPV DNA testing in the clinical setting. Instituto Oswaldo Cruz, Ministério da Saúde 2016-02 /pmc/articles/PMC4750452/ /pubmed/26872340 http://dx.doi.org/10.1590/0074-02760150393 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Meyrelles, Angela RI
Siqueira, Juliana D
dos Santos, Pâmela P
Hofer, Cristina B
Luiz, Ronir R
Seuánez, Héctor N
Almeida, Gutemberg
Soares, Marcelo A
Soares, Esmeralda A
Machado, Elizabeth S
Bonafide, type-specific human papillomavirus persistence among HIV-positive pregnant women: predictive value for cytological abnormalities, a longitudinal cohort study
title Bonafide, type-specific human papillomavirus persistence among HIV-positive pregnant women: predictive value for cytological abnormalities, a longitudinal cohort study
title_full Bonafide, type-specific human papillomavirus persistence among HIV-positive pregnant women: predictive value for cytological abnormalities, a longitudinal cohort study
title_fullStr Bonafide, type-specific human papillomavirus persistence among HIV-positive pregnant women: predictive value for cytological abnormalities, a longitudinal cohort study
title_full_unstemmed Bonafide, type-specific human papillomavirus persistence among HIV-positive pregnant women: predictive value for cytological abnormalities, a longitudinal cohort study
title_short Bonafide, type-specific human papillomavirus persistence among HIV-positive pregnant women: predictive value for cytological abnormalities, a longitudinal cohort study
title_sort bonafide, type-specific human papillomavirus persistence among hiv-positive pregnant women: predictive value for cytological abnormalities, a longitudinal cohort study
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750452/
https://www.ncbi.nlm.nih.gov/pubmed/26872340
http://dx.doi.org/10.1590/0074-02760150393
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