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Systems Perturbation Analysis of a Large-Scale Signal Transduction Model Reveals Potentially Influential Candidates for Cancer Therapeutics

Dysregulation in signal transduction pathways can lead to a variety of complex disorders, including cancer. Computational approaches such as network analysis are important tools to understand system dynamics as well as to identify critical components that could be further explored as therapeutic tar...

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Detalles Bibliográficos
Autores principales:	Puniya, Bhanwar Lal, Allen, Laura, Hochfelder, Colleen, Majumder, Mahbubul, Helikar, Tomáš
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750464/ https://www.ncbi.nlm.nih.gov/pubmed/26904540 http://dx.doi.org/10.3389/fbioe.2016.00010

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