Cargando…
Systems Perturbation Analysis of a Large-Scale Signal Transduction Model Reveals Potentially Influential Candidates for Cancer Therapeutics
Dysregulation in signal transduction pathways can lead to a variety of complex disorders, including cancer. Computational approaches such as network analysis are important tools to understand system dynamics as well as to identify critical components that could be further explored as therapeutic tar...
Autores principales: | Puniya, Bhanwar Lal, Allen, Laura, Hochfelder, Colleen, Majumder, Mahbubul, Helikar, Tomáš |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750464/ https://www.ncbi.nlm.nih.gov/pubmed/26904540 http://dx.doi.org/10.3389/fbioe.2016.00010 |
Ejemplares similares
-
A multiscale mechanistic model of human dendritic cells for in-silico investigation of immune responses and novel therapeutics discovery
por: Aghamiri, Sara Sadat, et al.
Publicado: (2023) -
A multi-approach and multi-scale platform to model CD4+ T cells responding to infections
por: Wertheim, Kenneth Y., et al.
Publicado: (2021) -
Identification of Biologically Essential Nodes via Determinative Power in Logical Models of Cellular Processes
por: Pentzien, Trevor, et al.
Publicado: (2018) -
A Mechanistic Computational Model Reveals That Plasticity of CD4(+) T Cell Differentiation Is a Function of Cytokine Composition and Dosage
por: Puniya, Bhanwar Lal, et al.
Publicado: (2018) -
Arginine Catabolism and Polyamine Biosynthesis Pathway Disparities Within Francisella tularensis Subpopulations
por: Yue, Yinshi, et al.
Publicado: (2022)