Effects of FVIII immunity on hepatocyte and hematopoietic stem cell–directed gene therapy of murine hemophilia A

Immune responses to coagulation factors VIII (FVIII) and IX (FIX) represent primary obstacles to hemophilia treatment. Previously, we showed that hematopoietic stem cell (HSC) retroviral gene therapy induces immune nonresponsiveness to FVIII in both naive and preimmunized murine hemophilia A setting...

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Detalles Bibliográficos
Autores principales: Lytle, Allison M, Brown, Harrison C, Paik, Na Yoon, Knight, Kristopher A, Wright, J Fraser, Spencer, H Trent, Doering, Christopher B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750467/
https://www.ncbi.nlm.nih.gov/pubmed/26909355
http://dx.doi.org/10.1038/mtm.2015.56

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750467/
https://www.ncbi.nlm.nih.gov/pubmed/26909355
http://dx.doi.org/10.1038/mtm.2015.56

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