The role of piRNA and its potential clinical implications in cancer

Epigenetic mechanisms work in an orchestrated fashion to control gene expression in both homeostasis and diseases. Among small noncoding RNAs, piRNAs seem to meet the necessary requirements to be included in this epigenetic network due to their role in both transcriptional and post-transcriptional r...

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Autores principales: Assumpção, Carolina Baraúna, Calcagno, Danielle Queiroz, Araújo, Taíssa Maíra Thomaz, dos Santos, Sidney Emmanuel Batista, dos Santos, Ândrea Kely Campos Ribeiro, Riggins, Gregory Joseph, Burbano, Rommel Rodriguez, Assumpção, Paulo Pimentel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750480/
https://www.ncbi.nlm.nih.gov/pubmed/25929784
http://dx.doi.org/10.2217/epi.15.37
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author Assumpção, Carolina Baraúna
Calcagno, Danielle Queiroz
Araújo, Taíssa Maíra Thomaz
dos Santos, Sidney Emmanuel Batista
dos Santos, Ândrea Kely Campos Ribeiro
Riggins, Gregory Joseph
Burbano, Rommel Rodriguez
Assumpção, Paulo Pimentel
author_facet Assumpção, Carolina Baraúna
Calcagno, Danielle Queiroz
Araújo, Taíssa Maíra Thomaz
dos Santos, Sidney Emmanuel Batista
dos Santos, Ândrea Kely Campos Ribeiro
Riggins, Gregory Joseph
Burbano, Rommel Rodriguez
Assumpção, Paulo Pimentel
author_sort Assumpção, Carolina Baraúna
collection PubMed
description Epigenetic mechanisms work in an orchestrated fashion to control gene expression in both homeostasis and diseases. Among small noncoding RNAs, piRNAs seem to meet the necessary requirements to be included in this epigenetic network due to their role in both transcriptional and post-transcriptional regulation. piRNAs and PIWI proteins might play important roles in cancer occurrence, prognosis and treatment as reported previously. Nevertheless, the potential clinical relevance of these molecules has yet been elucidated. A brief overview of piRNA biogenesis and their potential roles as part of an epigenetic network that is possibly involved in cancer is provided. Moreover, potential strategies based on the use of piRNAs and PIWI proteins as diagnostic and prognostic biomarkers as well as for cancer therapeutics are discussed.
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spelling pubmed-47504802016-02-11 The role of piRNA and its potential clinical implications in cancer Assumpção, Carolina Baraúna Calcagno, Danielle Queiroz Araújo, Taíssa Maíra Thomaz dos Santos, Sidney Emmanuel Batista dos Santos, Ândrea Kely Campos Ribeiro Riggins, Gregory Joseph Burbano, Rommel Rodriguez Assumpção, Paulo Pimentel Epigenomics Article Epigenetic mechanisms work in an orchestrated fashion to control gene expression in both homeostasis and diseases. Among small noncoding RNAs, piRNAs seem to meet the necessary requirements to be included in this epigenetic network due to their role in both transcriptional and post-transcriptional regulation. piRNAs and PIWI proteins might play important roles in cancer occurrence, prognosis and treatment as reported previously. Nevertheless, the potential clinical relevance of these molecules has yet been elucidated. A brief overview of piRNA biogenesis and their potential roles as part of an epigenetic network that is possibly involved in cancer is provided. Moreover, potential strategies based on the use of piRNAs and PIWI proteins as diagnostic and prognostic biomarkers as well as for cancer therapeutics are discussed. 2015-05-01 2015-09 /pmc/articles/PMC4750480/ /pubmed/25929784 http://dx.doi.org/10.2217/epi.15.37 Text en This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Article
Assumpção, Carolina Baraúna
Calcagno, Danielle Queiroz
Araújo, Taíssa Maíra Thomaz
dos Santos, Sidney Emmanuel Batista
dos Santos, Ândrea Kely Campos Ribeiro
Riggins, Gregory Joseph
Burbano, Rommel Rodriguez
Assumpção, Paulo Pimentel
The role of piRNA and its potential clinical implications in cancer
title The role of piRNA and its potential clinical implications in cancer
title_full The role of piRNA and its potential clinical implications in cancer
title_fullStr The role of piRNA and its potential clinical implications in cancer
title_full_unstemmed The role of piRNA and its potential clinical implications in cancer
title_short The role of piRNA and its potential clinical implications in cancer
title_sort role of pirna and its potential clinical implications in cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750480/
https://www.ncbi.nlm.nih.gov/pubmed/25929784
http://dx.doi.org/10.2217/epi.15.37
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