Cargando…

An innovative approach to investigate the dynamics of the cerebrospinal fluid in the prepontine cistern: A feasibility study using spatial saturation-prepared cine PC-MRI

PURPOSES: Accurate measurements of the cerebrospinal fluid that flows through the prepontine cistern (PPC) are challenging due to artefacts originating from basilar artery blood flow. We aim to accurately quantify cerebrospinal fluid (CSF) flow and stroke volume in the PPC, which is essential before...

Descripción completa

Detalles Bibliográficos
Autores principales: Rüegger, Christoph M., Makki, Malek I., Capel, Cyrille, Gondry-Jouet, Catherine, Baledent, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750628/
https://www.ncbi.nlm.nih.gov/pubmed/26937424
http://dx.doi.org/10.1016/j.ejro.2014.09.005
_version_ 1782415462702776320
author Rüegger, Christoph M.
Makki, Malek I.
Capel, Cyrille
Gondry-Jouet, Catherine
Baledent, Olivier
author_facet Rüegger, Christoph M.
Makki, Malek I.
Capel, Cyrille
Gondry-Jouet, Catherine
Baledent, Olivier
author_sort Rüegger, Christoph M.
collection PubMed
description PURPOSES: Accurate measurements of the cerebrospinal fluid that flows through the prepontine cistern (PPC) are challenging due to artefacts originating from basilar artery blood flow. We aim to accurately quantify cerebrospinal fluid (CSF) flow and stroke volume in the PPC, which is essential before endoscopic third ventriculostomy. MATERIALS AND METHODS: We developed a new PC-MRI sequence prepared with Hadamard saturation bands to accurately quantify CSF flow in the PPC by suppressing the blood signal in the surrounding vessels. In total, 28 adult hydrocephalic patients (age 59 ± 20 years) were scanned using conventional PC-MRI and our developed sequence. CSF was separately extracted from the PPC and the foramen of Magendie, and flow (min and max) and stroke volume were quantified. RESULTS: Our modifications result in a complete deletion of signal from flowing blood, resulting in significantly reduced CSF stroke volume (Conv = 446 ± 113 mm(3), Dev = 390 ± 119 mm(3), p = 0.006) and flow, both minimum (Conv = −1630 ± 486 mm(3)/s, Dev = −1430 ± 406 mm(3)/s, p = 0.005) and maximum (Conv = 2384 ± 657 mm(3)/s, Dev = 1971 ± 62 mm(3)/s, p = 0.002) compared with the conventional sequence, whereas no change in the area of interest was noted (Conv = 236 ± 65 mm(2), Dev = 249 ± 75 mm(2), p = 0.21). CONCLUSIONS: Accurate and reproducible CSF flow and stroke volume measurements in the PPC can be achieved with sat-band prepared cine PC-MRI.
format Online
Article
Text
id pubmed-4750628
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-47506282016-03-02 An innovative approach to investigate the dynamics of the cerebrospinal fluid in the prepontine cistern: A feasibility study using spatial saturation-prepared cine PC-MRI Rüegger, Christoph M. Makki, Malek I. Capel, Cyrille Gondry-Jouet, Catherine Baledent, Olivier Eur J Radiol Open Article PURPOSES: Accurate measurements of the cerebrospinal fluid that flows through the prepontine cistern (PPC) are challenging due to artefacts originating from basilar artery blood flow. We aim to accurately quantify cerebrospinal fluid (CSF) flow and stroke volume in the PPC, which is essential before endoscopic third ventriculostomy. MATERIALS AND METHODS: We developed a new PC-MRI sequence prepared with Hadamard saturation bands to accurately quantify CSF flow in the PPC by suppressing the blood signal in the surrounding vessels. In total, 28 adult hydrocephalic patients (age 59 ± 20 years) were scanned using conventional PC-MRI and our developed sequence. CSF was separately extracted from the PPC and the foramen of Magendie, and flow (min and max) and stroke volume were quantified. RESULTS: Our modifications result in a complete deletion of signal from flowing blood, resulting in significantly reduced CSF stroke volume (Conv = 446 ± 113 mm(3), Dev = 390 ± 119 mm(3), p = 0.006) and flow, both minimum (Conv = −1630 ± 486 mm(3)/s, Dev = −1430 ± 406 mm(3)/s, p = 0.005) and maximum (Conv = 2384 ± 657 mm(3)/s, Dev = 1971 ± 62 mm(3)/s, p = 0.002) compared with the conventional sequence, whereas no change in the area of interest was noted (Conv = 236 ± 65 mm(2), Dev = 249 ± 75 mm(2), p = 0.21). CONCLUSIONS: Accurate and reproducible CSF flow and stroke volume measurements in the PPC can be achieved with sat-band prepared cine PC-MRI. Elsevier 2014-10-16 /pmc/articles/PMC4750628/ /pubmed/26937424 http://dx.doi.org/10.1016/j.ejro.2014.09.005 Text en © 2014 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
Rüegger, Christoph M.
Makki, Malek I.
Capel, Cyrille
Gondry-Jouet, Catherine
Baledent, Olivier
An innovative approach to investigate the dynamics of the cerebrospinal fluid in the prepontine cistern: A feasibility study using spatial saturation-prepared cine PC-MRI
title An innovative approach to investigate the dynamics of the cerebrospinal fluid in the prepontine cistern: A feasibility study using spatial saturation-prepared cine PC-MRI
title_full An innovative approach to investigate the dynamics of the cerebrospinal fluid in the prepontine cistern: A feasibility study using spatial saturation-prepared cine PC-MRI
title_fullStr An innovative approach to investigate the dynamics of the cerebrospinal fluid in the prepontine cistern: A feasibility study using spatial saturation-prepared cine PC-MRI
title_full_unstemmed An innovative approach to investigate the dynamics of the cerebrospinal fluid in the prepontine cistern: A feasibility study using spatial saturation-prepared cine PC-MRI
title_short An innovative approach to investigate the dynamics of the cerebrospinal fluid in the prepontine cistern: A feasibility study using spatial saturation-prepared cine PC-MRI
title_sort innovative approach to investigate the dynamics of the cerebrospinal fluid in the prepontine cistern: a feasibility study using spatial saturation-prepared cine pc-mri
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750628/
https://www.ncbi.nlm.nih.gov/pubmed/26937424
http://dx.doi.org/10.1016/j.ejro.2014.09.005
work_keys_str_mv AT rueggerchristophm aninnovativeapproachtoinvestigatethedynamicsofthecerebrospinalfluidintheprepontinecisternafeasibilitystudyusingspatialsaturationpreparedcinepcmri
AT makkimaleki aninnovativeapproachtoinvestigatethedynamicsofthecerebrospinalfluidintheprepontinecisternafeasibilitystudyusingspatialsaturationpreparedcinepcmri
AT capelcyrille aninnovativeapproachtoinvestigatethedynamicsofthecerebrospinalfluidintheprepontinecisternafeasibilitystudyusingspatialsaturationpreparedcinepcmri
AT gondryjouetcatherine aninnovativeapproachtoinvestigatethedynamicsofthecerebrospinalfluidintheprepontinecisternafeasibilitystudyusingspatialsaturationpreparedcinepcmri
AT baledentolivier aninnovativeapproachtoinvestigatethedynamicsofthecerebrospinalfluidintheprepontinecisternafeasibilitystudyusingspatialsaturationpreparedcinepcmri
AT rueggerchristophm innovativeapproachtoinvestigatethedynamicsofthecerebrospinalfluidintheprepontinecisternafeasibilitystudyusingspatialsaturationpreparedcinepcmri
AT makkimaleki innovativeapproachtoinvestigatethedynamicsofthecerebrospinalfluidintheprepontinecisternafeasibilitystudyusingspatialsaturationpreparedcinepcmri
AT capelcyrille innovativeapproachtoinvestigatethedynamicsofthecerebrospinalfluidintheprepontinecisternafeasibilitystudyusingspatialsaturationpreparedcinepcmri
AT gondryjouetcatherine innovativeapproachtoinvestigatethedynamicsofthecerebrospinalfluidintheprepontinecisternafeasibilitystudyusingspatialsaturationpreparedcinepcmri
AT baledentolivier innovativeapproachtoinvestigatethedynamicsofthecerebrospinalfluidintheprepontinecisternafeasibilitystudyusingspatialsaturationpreparedcinepcmri