Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue

Methylenetetrahydrofolate reductase (MTHFR) is an enzyme key regulator in folate metabolism. Deficiencies in MTHFR result in increased levels of homocysteine, which leads to reduced levels of S-adenosylmethionine (SAM). In the brain, SAM donates methyl groups to catechol-O-methyltransferase (COMT),...

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Detalles Bibliográficos
Autores principales: Jadavji, N.M., Wieske, F., Dirnagl, U., Winter, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750636/
https://www.ncbi.nlm.nih.gov/pubmed/26937386
http://dx.doi.org/10.1016/j.ymgmr.2015.02.001

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