Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus

Toxicity has emerged during the clinical development of many but not all nucleotide inhibitors (NI) of hepatitis C virus (HCV). To better understand the mechanism for adverse events, clinically relevant HCV NI were characterized in biochemical and cellular assays, including assays of decreased viabi...

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Detalles Bibliográficos
Autores principales: Feng, Joy Y., Xu, Yili, Barauskas, Ona, Perry, Jason K., Ahmadyar, Shekeba, Stepan, George, Yu, Helen, Babusis, Darius, Park, Yeojin, McCutcheon, Krista, Perron, Michel, Schultz, Brian E., Sakowicz, Roman, Ray, Adrian S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750701/
https://www.ncbi.nlm.nih.gov/pubmed/26596942
http://dx.doi.org/10.1128/AAC.01922-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750701/
https://www.ncbi.nlm.nih.gov/pubmed/26596942
http://dx.doi.org/10.1128/AAC.01922-15

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