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Influence of Selective Biochemical and Morphological Agents on Natural History of Aneurysm of Abdominal Aorta Development
BACKGROUND: The development of abdominal aortic aneurysm (AAA) is probably influenced by many factors. The role of some of these factors, such as intraluminal thrombus (ILT) or cystatin C serum levels, remains controversial. Proving their influence could have therapeutic implications for some patien...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750727/ https://www.ncbi.nlm.nih.gov/pubmed/26859744 http://dx.doi.org/10.12659/MSM.893639 |
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author | Wołoszko, Tomasz Skórski, Maciej Kwasiborski, Przemysław Kmin, Ewelina Gałązka, Zbigniew Pogorzelski, Ryszard |
author_facet | Wołoszko, Tomasz Skórski, Maciej Kwasiborski, Przemysław Kmin, Ewelina Gałązka, Zbigniew Pogorzelski, Ryszard |
author_sort | Wołoszko, Tomasz |
collection | PubMed |
description | BACKGROUND: The development of abdominal aortic aneurysm (AAA) is probably influenced by many factors. The role of some of these factors, such as intraluminal thrombus (ILT) or cystatin C serum levels, remains controversial. Proving their influence could have therapeutic implications for some patients with AAA. Associations between the rate of increase in diameter of an aneurysm and ILT, as well as other factors, including biochemical factors (C-Reactive Protein – CRP, cystatin C), age, sex, and comorbidities, could predict disease progression in individual patients. MATERIAL/METHODS: Seventy patients with small AAA were included into the study. The patients were followed using ultrasound and CT imaging. We evaluated aneurysm dimensions and aneurysm wall thickness, as well as ILT and its dimensions, aneurysm wall morphology, CRP, and cystatin C. RESULTS: We observed significant growth of AAA and thinning of aneurysmal wall. Aneurysms over 4 cm grew significantly faster in the second year of observation. ILT grew together with AAA size. Age, sex, smoking, dyslipidemias, or controlled arterial hypertension had no influence on aneurysm progression rate. Changes in serum of CRP concentration did not reach statistical significance, but cystatin C levels did. CONCLUSIONS: Presence and size of ILT, wall thickness, and cystatin C levels may be considered in prediction of AAA progression. ILT might exert a protective influence on the risk of aneurysm rupture. However, larger aneurysms containing larger thrombi grow faster and their walls undergo more rapid degradation, which in turn increases the risk of rupture. This matter requires further studies. |
format | Online Article Text |
id | pubmed-4750727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47507272016-02-19 Influence of Selective Biochemical and Morphological Agents on Natural History of Aneurysm of Abdominal Aorta Development Wołoszko, Tomasz Skórski, Maciej Kwasiborski, Przemysław Kmin, Ewelina Gałązka, Zbigniew Pogorzelski, Ryszard Med Sci Monit Clinical Research BACKGROUND: The development of abdominal aortic aneurysm (AAA) is probably influenced by many factors. The role of some of these factors, such as intraluminal thrombus (ILT) or cystatin C serum levels, remains controversial. Proving their influence could have therapeutic implications for some patients with AAA. Associations between the rate of increase in diameter of an aneurysm and ILT, as well as other factors, including biochemical factors (C-Reactive Protein – CRP, cystatin C), age, sex, and comorbidities, could predict disease progression in individual patients. MATERIAL/METHODS: Seventy patients with small AAA were included into the study. The patients were followed using ultrasound and CT imaging. We evaluated aneurysm dimensions and aneurysm wall thickness, as well as ILT and its dimensions, aneurysm wall morphology, CRP, and cystatin C. RESULTS: We observed significant growth of AAA and thinning of aneurysmal wall. Aneurysms over 4 cm grew significantly faster in the second year of observation. ILT grew together with AAA size. Age, sex, smoking, dyslipidemias, or controlled arterial hypertension had no influence on aneurysm progression rate. Changes in serum of CRP concentration did not reach statistical significance, but cystatin C levels did. CONCLUSIONS: Presence and size of ILT, wall thickness, and cystatin C levels may be considered in prediction of AAA progression. ILT might exert a protective influence on the risk of aneurysm rupture. However, larger aneurysms containing larger thrombi grow faster and their walls undergo more rapid degradation, which in turn increases the risk of rupture. This matter requires further studies. International Scientific Literature, Inc. 2016-02-09 /pmc/articles/PMC4750727/ /pubmed/26859744 http://dx.doi.org/10.12659/MSM.893639 Text en © Med Sci Monit, 2016 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
spellingShingle | Clinical Research Wołoszko, Tomasz Skórski, Maciej Kwasiborski, Przemysław Kmin, Ewelina Gałązka, Zbigniew Pogorzelski, Ryszard Influence of Selective Biochemical and Morphological Agents on Natural History of Aneurysm of Abdominal Aorta Development |
title | Influence of Selective Biochemical and Morphological Agents on Natural History of Aneurysm of Abdominal Aorta Development |
title_full | Influence of Selective Biochemical and Morphological Agents on Natural History of Aneurysm of Abdominal Aorta Development |
title_fullStr | Influence of Selective Biochemical and Morphological Agents on Natural History of Aneurysm of Abdominal Aorta Development |
title_full_unstemmed | Influence of Selective Biochemical and Morphological Agents on Natural History of Aneurysm of Abdominal Aorta Development |
title_short | Influence of Selective Biochemical and Morphological Agents on Natural History of Aneurysm of Abdominal Aorta Development |
title_sort | influence of selective biochemical and morphological agents on natural history of aneurysm of abdominal aorta development |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750727/ https://www.ncbi.nlm.nih.gov/pubmed/26859744 http://dx.doi.org/10.12659/MSM.893639 |
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