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Influence of Selective Biochemical and Morphological Agents on Natural History of Aneurysm of Abdominal Aorta Development

BACKGROUND: The development of abdominal aortic aneurysm (AAA) is probably influenced by many factors. The role of some of these factors, such as intraluminal thrombus (ILT) or cystatin C serum levels, remains controversial. Proving their influence could have therapeutic implications for some patien...

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Autores principales: Wołoszko, Tomasz, Skórski, Maciej, Kwasiborski, Przemysław, Kmin, Ewelina, Gałązka, Zbigniew, Pogorzelski, Ryszard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750727/
https://www.ncbi.nlm.nih.gov/pubmed/26859744
http://dx.doi.org/10.12659/MSM.893639
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author Wołoszko, Tomasz
Skórski, Maciej
Kwasiborski, Przemysław
Kmin, Ewelina
Gałązka, Zbigniew
Pogorzelski, Ryszard
author_facet Wołoszko, Tomasz
Skórski, Maciej
Kwasiborski, Przemysław
Kmin, Ewelina
Gałązka, Zbigniew
Pogorzelski, Ryszard
author_sort Wołoszko, Tomasz
collection PubMed
description BACKGROUND: The development of abdominal aortic aneurysm (AAA) is probably influenced by many factors. The role of some of these factors, such as intraluminal thrombus (ILT) or cystatin C serum levels, remains controversial. Proving their influence could have therapeutic implications for some patients with AAA. Associations between the rate of increase in diameter of an aneurysm and ILT, as well as other factors, including biochemical factors (C-Reactive Protein – CRP, cystatin C), age, sex, and comorbidities, could predict disease progression in individual patients. MATERIAL/METHODS: Seventy patients with small AAA were included into the study. The patients were followed using ultrasound and CT imaging. We evaluated aneurysm dimensions and aneurysm wall thickness, as well as ILT and its dimensions, aneurysm wall morphology, CRP, and cystatin C. RESULTS: We observed significant growth of AAA and thinning of aneurysmal wall. Aneurysms over 4 cm grew significantly faster in the second year of observation. ILT grew together with AAA size. Age, sex, smoking, dyslipidemias, or controlled arterial hypertension had no influence on aneurysm progression rate. Changes in serum of CRP concentration did not reach statistical significance, but cystatin C levels did. CONCLUSIONS: Presence and size of ILT, wall thickness, and cystatin C levels may be considered in prediction of AAA progression. ILT might exert a protective influence on the risk of aneurysm rupture. However, larger aneurysms containing larger thrombi grow faster and their walls undergo more rapid degradation, which in turn increases the risk of rupture. This matter requires further studies.
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spelling pubmed-47507272016-02-19 Influence of Selective Biochemical and Morphological Agents on Natural History of Aneurysm of Abdominal Aorta Development Wołoszko, Tomasz Skórski, Maciej Kwasiborski, Przemysław Kmin, Ewelina Gałązka, Zbigniew Pogorzelski, Ryszard Med Sci Monit Clinical Research BACKGROUND: The development of abdominal aortic aneurysm (AAA) is probably influenced by many factors. The role of some of these factors, such as intraluminal thrombus (ILT) or cystatin C serum levels, remains controversial. Proving their influence could have therapeutic implications for some patients with AAA. Associations between the rate of increase in diameter of an aneurysm and ILT, as well as other factors, including biochemical factors (C-Reactive Protein – CRP, cystatin C), age, sex, and comorbidities, could predict disease progression in individual patients. MATERIAL/METHODS: Seventy patients with small AAA were included into the study. The patients were followed using ultrasound and CT imaging. We evaluated aneurysm dimensions and aneurysm wall thickness, as well as ILT and its dimensions, aneurysm wall morphology, CRP, and cystatin C. RESULTS: We observed significant growth of AAA and thinning of aneurysmal wall. Aneurysms over 4 cm grew significantly faster in the second year of observation. ILT grew together with AAA size. Age, sex, smoking, dyslipidemias, or controlled arterial hypertension had no influence on aneurysm progression rate. Changes in serum of CRP concentration did not reach statistical significance, but cystatin C levels did. CONCLUSIONS: Presence and size of ILT, wall thickness, and cystatin C levels may be considered in prediction of AAA progression. ILT might exert a protective influence on the risk of aneurysm rupture. However, larger aneurysms containing larger thrombi grow faster and their walls undergo more rapid degradation, which in turn increases the risk of rupture. This matter requires further studies. International Scientific Literature, Inc. 2016-02-09 /pmc/articles/PMC4750727/ /pubmed/26859744 http://dx.doi.org/10.12659/MSM.893639 Text en © Med Sci Monit, 2016 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Clinical Research
Wołoszko, Tomasz
Skórski, Maciej
Kwasiborski, Przemysław
Kmin, Ewelina
Gałązka, Zbigniew
Pogorzelski, Ryszard
Influence of Selective Biochemical and Morphological Agents on Natural History of Aneurysm of Abdominal Aorta Development
title Influence of Selective Biochemical and Morphological Agents on Natural History of Aneurysm of Abdominal Aorta Development
title_full Influence of Selective Biochemical and Morphological Agents on Natural History of Aneurysm of Abdominal Aorta Development
title_fullStr Influence of Selective Biochemical and Morphological Agents on Natural History of Aneurysm of Abdominal Aorta Development
title_full_unstemmed Influence of Selective Biochemical and Morphological Agents on Natural History of Aneurysm of Abdominal Aorta Development
title_short Influence of Selective Biochemical and Morphological Agents on Natural History of Aneurysm of Abdominal Aorta Development
title_sort influence of selective biochemical and morphological agents on natural history of aneurysm of abdominal aorta development
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750727/
https://www.ncbi.nlm.nih.gov/pubmed/26859744
http://dx.doi.org/10.12659/MSM.893639
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