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Clinical attributes, treatment, and control in hypertension (CATCH)—a French and Italian longitudinal patient database study

INTRODUCTION: Hypertension, a risk factor for cardiovascular disease (CVD), is frequently associated with other CVD risk factors. Despite recent improvement in blood pressure (BP) control in Europe, a substantial proportion of patients fail to achieve BP targets. METHODS: This retrospective cohort s...

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Autores principales: Wu, David, Mansoor, George, Kempf, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750805/
https://www.ncbi.nlm.nih.gov/pubmed/26893928
http://dx.doi.org/10.1186/s40885-015-0029-2
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author Wu, David
Mansoor, George
Kempf, Christian
author_facet Wu, David
Mansoor, George
Kempf, Christian
author_sort Wu, David
collection PubMed
description INTRODUCTION: Hypertension, a risk factor for cardiovascular disease (CVD), is frequently associated with other CVD risk factors. Despite recent improvement in blood pressure (BP) control in Europe, a substantial proportion of patients fail to achieve BP targets. METHODS: This retrospective cohort study used longitudinal patient databases (LPDs) in France and Italy to examine CVD risk profiles, treatment patterns, and BP goal attainment in hypertensive patients treated in real-world clinical practice between 2007 and 2008. Overall, 147,964 and 140,189 eligible patients from LPDs in France and Italy, respectively, were prescribed an antihypertensive medication in 2007. RESULTS: Among patients with hypertension with other risk factors (France 88 %, Italy 83 %), the most prevalent risk factors were being elderly (France 66.9 %, Italy 70. 9 %), followed by hypertension combined with dyslipidemia (France 36.7 %, Italy 23.9 %) and isolated systolic hypertension (France 32.5 %, Italy 24.2 %). The odds ratios for target BP attainment were significantly (p < 0.001) higher in patients with hypertension without other risk factors vs patients with hypertension with other risk factors (1.41 [95 % confidence interval 1.35, 1.48] in France; 1.38 [1.31, 1.46] in Italy). The odds of BP control were significantly lower for patients with vs patients without an associated CVD risk factor (range 0.54 to 1.10 France; 0.59 to 1.17 Italy). DISCUSSION: This study demonstrates that the majority of treated hypertensive patients in France and Italy have at least one additional CVD risk factor. Despite treatment with antihypertensive medications, blood pressure attainment was substantially less optimal in patients with an associated CVD risk factor compared to patients without an associated CVD risk factor. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40885-015-0029-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-47508052016-02-18 Clinical attributes, treatment, and control in hypertension (CATCH)—a French and Italian longitudinal patient database study Wu, David Mansoor, George Kempf, Christian Clin Hypertens Research INTRODUCTION: Hypertension, a risk factor for cardiovascular disease (CVD), is frequently associated with other CVD risk factors. Despite recent improvement in blood pressure (BP) control in Europe, a substantial proportion of patients fail to achieve BP targets. METHODS: This retrospective cohort study used longitudinal patient databases (LPDs) in France and Italy to examine CVD risk profiles, treatment patterns, and BP goal attainment in hypertensive patients treated in real-world clinical practice between 2007 and 2008. Overall, 147,964 and 140,189 eligible patients from LPDs in France and Italy, respectively, were prescribed an antihypertensive medication in 2007. RESULTS: Among patients with hypertension with other risk factors (France 88 %, Italy 83 %), the most prevalent risk factors were being elderly (France 66.9 %, Italy 70. 9 %), followed by hypertension combined with dyslipidemia (France 36.7 %, Italy 23.9 %) and isolated systolic hypertension (France 32.5 %, Italy 24.2 %). The odds ratios for target BP attainment were significantly (p < 0.001) higher in patients with hypertension without other risk factors vs patients with hypertension with other risk factors (1.41 [95 % confidence interval 1.35, 1.48] in France; 1.38 [1.31, 1.46] in Italy). The odds of BP control were significantly lower for patients with vs patients without an associated CVD risk factor (range 0.54 to 1.10 France; 0.59 to 1.17 Italy). DISCUSSION: This study demonstrates that the majority of treated hypertensive patients in France and Italy have at least one additional CVD risk factor. Despite treatment with antihypertensive medications, blood pressure attainment was substantially less optimal in patients with an associated CVD risk factor compared to patients without an associated CVD risk factor. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40885-015-0029-2) contains supplementary material, which is available to authorized users. BioMed Central 2015-08-10 /pmc/articles/PMC4750805/ /pubmed/26893928 http://dx.doi.org/10.1186/s40885-015-0029-2 Text en © Wu et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Wu, David
Mansoor, George
Kempf, Christian
Clinical attributes, treatment, and control in hypertension (CATCH)—a French and Italian longitudinal patient database study
title Clinical attributes, treatment, and control in hypertension (CATCH)—a French and Italian longitudinal patient database study
title_full Clinical attributes, treatment, and control in hypertension (CATCH)—a French and Italian longitudinal patient database study
title_fullStr Clinical attributes, treatment, and control in hypertension (CATCH)—a French and Italian longitudinal patient database study
title_full_unstemmed Clinical attributes, treatment, and control in hypertension (CATCH)—a French and Italian longitudinal patient database study
title_short Clinical attributes, treatment, and control in hypertension (CATCH)—a French and Italian longitudinal patient database study
title_sort clinical attributes, treatment, and control in hypertension (catch)—a french and italian longitudinal patient database study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750805/
https://www.ncbi.nlm.nih.gov/pubmed/26893928
http://dx.doi.org/10.1186/s40885-015-0029-2
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