Cargando…

Phi Class of Glutathione S-transferase Gene Superfamily Widely Exists in Nonplant Taxonomic Groups

Glutathione S-transferases (GSTs) constitute a superfamily of enzymes involved in detoxification of noxious compounds and protection against oxidative damage. GST class Phi (GSTF), one of the important classes of plant GSTs, has long been considered as plant specific but was recently found in basidi...

Descripción completa

Detalles Bibliográficos
Autores principales: Munyampundu, Jean-Pierre, Xu, You-Ping, Cai, Xin-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750895/
https://www.ncbi.nlm.nih.gov/pubmed/26884677
http://dx.doi.org/10.4137/EBO.S35909
_version_ 1782415497185198080
author Munyampundu, Jean-Pierre
Xu, You-Ping
Cai, Xin-Zhong
author_facet Munyampundu, Jean-Pierre
Xu, You-Ping
Cai, Xin-Zhong
author_sort Munyampundu, Jean-Pierre
collection PubMed
description Glutathione S-transferases (GSTs) constitute a superfamily of enzymes involved in detoxification of noxious compounds and protection against oxidative damage. GST class Phi (GSTF), one of the important classes of plant GSTs, has long been considered as plant specific but was recently found in basidiomycete fungi. However, the range of nonplant taxonomic groups containing GSTFs remains unknown. In this study, the distribution and phylogenetic relationships of nonplant GSTFs were investigated. We identified GSTFs in ascomycete fungi, myxobacteria, and protists Naegleria gruberi and Aureococcus anophagefferens. GSTF occurrence in these bacteria and protists correlated with their genome sizes and habitats. While this link was missing across ascomycetes, the distribution and abundance of GSTFs among ascomycete genomes could be associated with their lifestyles to some extent. Sequence comparison, gene structure, and phylogenetic analyses indicated divergence among nonplant GSTFs, suggesting polyphyletic origins during evolution. Furthermore, in silico prediction of functional partners suggested functional diversification among nonplant GSTFs.
format Online
Article
Text
id pubmed-4750895
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Libertas Academica
record_format MEDLINE/PubMed
spelling pubmed-47508952016-02-16 Phi Class of Glutathione S-transferase Gene Superfamily Widely Exists in Nonplant Taxonomic Groups Munyampundu, Jean-Pierre Xu, You-Ping Cai, Xin-Zhong Evol Bioinform Online Original Research Glutathione S-transferases (GSTs) constitute a superfamily of enzymes involved in detoxification of noxious compounds and protection against oxidative damage. GST class Phi (GSTF), one of the important classes of plant GSTs, has long been considered as plant specific but was recently found in basidiomycete fungi. However, the range of nonplant taxonomic groups containing GSTFs remains unknown. In this study, the distribution and phylogenetic relationships of nonplant GSTFs were investigated. We identified GSTFs in ascomycete fungi, myxobacteria, and protists Naegleria gruberi and Aureococcus anophagefferens. GSTF occurrence in these bacteria and protists correlated with their genome sizes and habitats. While this link was missing across ascomycetes, the distribution and abundance of GSTFs among ascomycete genomes could be associated with their lifestyles to some extent. Sequence comparison, gene structure, and phylogenetic analyses indicated divergence among nonplant GSTFs, suggesting polyphyletic origins during evolution. Furthermore, in silico prediction of functional partners suggested functional diversification among nonplant GSTFs. Libertas Academica 2016-02-10 /pmc/articles/PMC4750895/ /pubmed/26884677 http://dx.doi.org/10.4137/EBO.S35909 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Original Research
Munyampundu, Jean-Pierre
Xu, You-Ping
Cai, Xin-Zhong
Phi Class of Glutathione S-transferase Gene Superfamily Widely Exists in Nonplant Taxonomic Groups
title Phi Class of Glutathione S-transferase Gene Superfamily Widely Exists in Nonplant Taxonomic Groups
title_full Phi Class of Glutathione S-transferase Gene Superfamily Widely Exists in Nonplant Taxonomic Groups
title_fullStr Phi Class of Glutathione S-transferase Gene Superfamily Widely Exists in Nonplant Taxonomic Groups
title_full_unstemmed Phi Class of Glutathione S-transferase Gene Superfamily Widely Exists in Nonplant Taxonomic Groups
title_short Phi Class of Glutathione S-transferase Gene Superfamily Widely Exists in Nonplant Taxonomic Groups
title_sort phi class of glutathione s-transferase gene superfamily widely exists in nonplant taxonomic groups
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750895/
https://www.ncbi.nlm.nih.gov/pubmed/26884677
http://dx.doi.org/10.4137/EBO.S35909
work_keys_str_mv AT munyampundujeanpierre phiclassofglutathionestransferasegenesuperfamilywidelyexistsinnonplanttaxonomicgroups
AT xuyouping phiclassofglutathionestransferasegenesuperfamilywidelyexistsinnonplanttaxonomicgroups
AT caixinzhong phiclassofglutathionestransferasegenesuperfamilywidelyexistsinnonplanttaxonomicgroups