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Glial Tau Pathology in Tauopathies: Functional Consequences
Tauopathies are a class of neurodegenerative diseases characterized by the presence of hyperphosphorylated and aggregated tau pathology in neuronal and glial cells. Though the ratio of neuronal and glial tau aggregates varies across diseases, glial tau aggregates can populate the same degenerating b...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750898/ https://www.ncbi.nlm.nih.gov/pubmed/26884683 http://dx.doi.org/10.4137/JEN.S25515 |
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author | Kahlson, Martha A. Colodner, Kenneth J. |
author_facet | Kahlson, Martha A. Colodner, Kenneth J. |
author_sort | Kahlson, Martha A. |
collection | PubMed |
description | Tauopathies are a class of neurodegenerative diseases characterized by the presence of hyperphosphorylated and aggregated tau pathology in neuronal and glial cells. Though the ratio of neuronal and glial tau aggregates varies across diseases, glial tau aggregates can populate the same degenerating brain regions as neuronal tau aggregates. While much is known about the deleterious consequences of tau pathology in neurons, the relative contribution of glial tau pathology to these diseases is less clear. Recent studies using a number of model systems implicate glial tau pathology in contributing to tauopathy pathogenesis. This review aims to highlight the functional consequences of tau overexpression in glial cells and explore the potential contribution of glial tau pathology in the pathogenesis of neurodegenerative tauopathies. |
format | Online Article Text |
id | pubmed-4750898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-47508982016-02-16 Glial Tau Pathology in Tauopathies: Functional Consequences Kahlson, Martha A. Colodner, Kenneth J. J Exp Neurosci Review Tauopathies are a class of neurodegenerative diseases characterized by the presence of hyperphosphorylated and aggregated tau pathology in neuronal and glial cells. Though the ratio of neuronal and glial tau aggregates varies across diseases, glial tau aggregates can populate the same degenerating brain regions as neuronal tau aggregates. While much is known about the deleterious consequences of tau pathology in neurons, the relative contribution of glial tau pathology to these diseases is less clear. Recent studies using a number of model systems implicate glial tau pathology in contributing to tauopathy pathogenesis. This review aims to highlight the functional consequences of tau overexpression in glial cells and explore the potential contribution of glial tau pathology in the pathogenesis of neurodegenerative tauopathies. Libertas Academica 2016-02-10 /pmc/articles/PMC4750898/ /pubmed/26884683 http://dx.doi.org/10.4137/JEN.S25515 Text en © 2015 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License. |
spellingShingle | Review Kahlson, Martha A. Colodner, Kenneth J. Glial Tau Pathology in Tauopathies: Functional Consequences |
title | Glial Tau Pathology in Tauopathies: Functional Consequences |
title_full | Glial Tau Pathology in Tauopathies: Functional Consequences |
title_fullStr | Glial Tau Pathology in Tauopathies: Functional Consequences |
title_full_unstemmed | Glial Tau Pathology in Tauopathies: Functional Consequences |
title_short | Glial Tau Pathology in Tauopathies: Functional Consequences |
title_sort | glial tau pathology in tauopathies: functional consequences |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750898/ https://www.ncbi.nlm.nih.gov/pubmed/26884683 http://dx.doi.org/10.4137/JEN.S25515 |
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