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Control of genetic stability by a new heterochromatin compaction pathway involving the Tip60 histone acetyltransferase

Pericentric heterochromatin is a highly compacted structure required for accurate chromosome segregation in mitosis. In mammals, it relies on methylation of histone H3K9 by Suv39H enzymes, which provides a docking site for HP1 proteins, therefore mediating heterochromatin compaction. Here we show th...

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Detalles Bibliográficos
Autores principales: Grézy, Aude, Chevillard-Briet, Martine, Trouche, Didier, Escaffit, Fabrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750920/
https://www.ncbi.nlm.nih.gov/pubmed/26700317
http://dx.doi.org/10.1091/mbc.E15-05-0316