Inhibition of the histone demethylase Kdm5b promotes neurogenesis and derepresses Reln (reelin) in neural stem cells from the adult subventricular zone of mice

The role of epigenetic regulators in the control of adult neurogenesis is largely undefined. We show that the histone demethylase enzyme Kdm5b (Jarid1b) negatively regulates neurogenesis from adult subventricular zone (SVZ) neural stem cells (NSCs) in culture. shRNA-mediated depletion of Kdm5b in pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Qiong, Obana, Edwin A., Radomski, Kryslaine L., Sukumar, Gauthaman, Wynder, Christopher, Dalgard, Clifton L., Doughty, Martin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750923/
https://www.ncbi.nlm.nih.gov/pubmed/26739753
http://dx.doi.org/10.1091/mbc.E15-07-0513

Ejemplares similares

Ejemplares similares