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Synergistic Combination of Electrolysis and Electroporation for Tissue Ablation
Electrolysis, electrochemotherapy with reversible electroporation, nanosecond pulsed electric fields and irreversible electroporation are valuable non-thermal electricity based tissue ablation technologies. This paper reports results from the first large animal study of a new non-thermal tissue abla...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750947/ https://www.ncbi.nlm.nih.gov/pubmed/26866693 http://dx.doi.org/10.1371/journal.pone.0148317 |
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author | Stehling, Michael K. Guenther, Enric Mikus, Paul Klein, Nina Rubinsky, Liel Rubinsky, Boris |
author_facet | Stehling, Michael K. Guenther, Enric Mikus, Paul Klein, Nina Rubinsky, Liel Rubinsky, Boris |
author_sort | Stehling, Michael K. |
collection | PubMed |
description | Electrolysis, electrochemotherapy with reversible electroporation, nanosecond pulsed electric fields and irreversible electroporation are valuable non-thermal electricity based tissue ablation technologies. This paper reports results from the first large animal study of a new non-thermal tissue ablation technology that employs “Synergistic electrolysis and electroporation” (SEE). The goal of this pre-clinical study is to expand on earlier studies with small animals and use the pig liver to establish SEE treatment parameters of clinical utility. We examined two SEE methods. One of the methods employs multiple electrochemotherapy-type reversible electroporation magnitude pulses, designed in such a way that the charge delivered during the electroporation pulses generates the electrolytic products. The second SEE method combines the delivery of a small number of electrochemotherapy magnitude electroporation pulses with a low voltage electrolysis generating DC current in three different ways. We show that both methods can produce lesion with dimensions of clinical utility, without the need to inject drugs as in electrochemotherapy, faster than with conventional electrolysis and with lower electric fields than irreversible electroporation and nanosecond pulsed ablation. |
format | Online Article Text |
id | pubmed-4750947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47509472016-02-26 Synergistic Combination of Electrolysis and Electroporation for Tissue Ablation Stehling, Michael K. Guenther, Enric Mikus, Paul Klein, Nina Rubinsky, Liel Rubinsky, Boris PLoS One Research Article Electrolysis, electrochemotherapy with reversible electroporation, nanosecond pulsed electric fields and irreversible electroporation are valuable non-thermal electricity based tissue ablation technologies. This paper reports results from the first large animal study of a new non-thermal tissue ablation technology that employs “Synergistic electrolysis and electroporation” (SEE). The goal of this pre-clinical study is to expand on earlier studies with small animals and use the pig liver to establish SEE treatment parameters of clinical utility. We examined two SEE methods. One of the methods employs multiple electrochemotherapy-type reversible electroporation magnitude pulses, designed in such a way that the charge delivered during the electroporation pulses generates the electrolytic products. The second SEE method combines the delivery of a small number of electrochemotherapy magnitude electroporation pulses with a low voltage electrolysis generating DC current in three different ways. We show that both methods can produce lesion with dimensions of clinical utility, without the need to inject drugs as in electrochemotherapy, faster than with conventional electrolysis and with lower electric fields than irreversible electroporation and nanosecond pulsed ablation. Public Library of Science 2016-02-11 /pmc/articles/PMC4750947/ /pubmed/26866693 http://dx.doi.org/10.1371/journal.pone.0148317 Text en © 2016 Stehling et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Stehling, Michael K. Guenther, Enric Mikus, Paul Klein, Nina Rubinsky, Liel Rubinsky, Boris Synergistic Combination of Electrolysis and Electroporation for Tissue Ablation |
title | Synergistic Combination of Electrolysis and Electroporation for Tissue Ablation |
title_full | Synergistic Combination of Electrolysis and Electroporation for Tissue Ablation |
title_fullStr | Synergistic Combination of Electrolysis and Electroporation for Tissue Ablation |
title_full_unstemmed | Synergistic Combination of Electrolysis and Electroporation for Tissue Ablation |
title_short | Synergistic Combination of Electrolysis and Electroporation for Tissue Ablation |
title_sort | synergistic combination of electrolysis and electroporation for tissue ablation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750947/ https://www.ncbi.nlm.nih.gov/pubmed/26866693 http://dx.doi.org/10.1371/journal.pone.0148317 |
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