Expression of NG2 proteoglycan in the degenerated intervertebral disc in dachshunds

The pathogenesis of intervertebral disc (IVD) degeneration is not fully understood. The biomolecular signaling pathways involved in the IVD degeneration require further investigation. The aim of this study was to investigate the expression of NG2 proteoglycan in the degenerated IVD. IVD samples were...

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Autores principales: ABDEL-HAKIEM, Mohammed, YAMASHITA, Ayuko, ATIBA, Ayman, OKAMURA, Yasuhiko, KATAYAMA, Masaaki, YOUSSEF, Haroun, ISOMURA, Hiroshi, UZUKA, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2015
Materias:
Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751123/
https://www.ncbi.nlm.nih.gov/pubmed/26300439
http://dx.doi.org/10.1292/jvms.14-0233
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author ABDEL-HAKIEM, Mohammed
YAMASHITA, Ayuko
ATIBA, Ayman
OKAMURA, Yasuhiko
KATAYAMA, Masaaki
YOUSSEF, Haroun
ISOMURA, Hiroshi
UZUKA, Yuji
author_facet ABDEL-HAKIEM, Mohammed
YAMASHITA, Ayuko
ATIBA, Ayman
OKAMURA, Yasuhiko
KATAYAMA, Masaaki
YOUSSEF, Haroun
ISOMURA, Hiroshi
UZUKA, Yuji
author_sort ABDEL-HAKIEM, Mohammed
collection PubMed
description The pathogenesis of intervertebral disc (IVD) degeneration is not fully understood. The biomolecular signaling pathways involved in the IVD degeneration require further investigation. The aim of this study was to investigate the expression of NG2 proteoglycan in the degenerated IVD. IVD samples were obtained from 16 Dachshunds that were confirmed to have IVD herniation and subsequently underwent hemilaminectomy. The samples were subjected to histological and immunohistochemical (IHC) examinations. IHC revealed positive results for the expression of NG2 proteoglycan in all examined samples. The results showed the expression of NG2 proteoglycan by the degenerated IVDs.
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spelling pubmed-47511232016-02-26 Expression of NG2 proteoglycan in the degenerated intervertebral disc in dachshunds ABDEL-HAKIEM, Mohammed YAMASHITA, Ayuko ATIBA, Ayman OKAMURA, Yasuhiko KATAYAMA, Masaaki YOUSSEF, Haroun ISOMURA, Hiroshi UZUKA, Yuji J Vet Med Sci Surgery The pathogenesis of intervertebral disc (IVD) degeneration is not fully understood. The biomolecular signaling pathways involved in the IVD degeneration require further investigation. The aim of this study was to investigate the expression of NG2 proteoglycan in the degenerated IVD. IVD samples were obtained from 16 Dachshunds that were confirmed to have IVD herniation and subsequently underwent hemilaminectomy. The samples were subjected to histological and immunohistochemical (IHC) examinations. IHC revealed positive results for the expression of NG2 proteoglycan in all examined samples. The results showed the expression of NG2 proteoglycan by the degenerated IVDs. The Japanese Society of Veterinary Science 2015-08-21 2016-01 /pmc/articles/PMC4751123/ /pubmed/26300439 http://dx.doi.org/10.1292/jvms.14-0233 Text en ©2016 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Surgery
ABDEL-HAKIEM, Mohammed
YAMASHITA, Ayuko
ATIBA, Ayman
OKAMURA, Yasuhiko
KATAYAMA, Masaaki
YOUSSEF, Haroun
ISOMURA, Hiroshi
UZUKA, Yuji
Expression of NG2 proteoglycan in the degenerated intervertebral disc in dachshunds
title Expression of NG2 proteoglycan in the degenerated intervertebral disc in dachshunds
title_full Expression of NG2 proteoglycan in the degenerated intervertebral disc in dachshunds
title_fullStr Expression of NG2 proteoglycan in the degenerated intervertebral disc in dachshunds
title_full_unstemmed Expression of NG2 proteoglycan in the degenerated intervertebral disc in dachshunds
title_short Expression of NG2 proteoglycan in the degenerated intervertebral disc in dachshunds
title_sort expression of ng2 proteoglycan in the degenerated intervertebral disc in dachshunds
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751123/
https://www.ncbi.nlm.nih.gov/pubmed/26300439
http://dx.doi.org/10.1292/jvms.14-0233
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