Effects of inactive parapoxvirus ovis on cytokine levels in rats

The aim of this study is to determine the effects of iPPOV on pro-inflammatory and anti-inflammatory cytokine levels in rats. iPPOV (1 ml/rat) was administered intraperitoneal route to 49 rats, except for 7 rats (Control, 0 group). Serum samples were collected from 7 rats at 1st, 2nd, 4th, 8th, 12th...

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Autores principales: AVCI, Oguzhan, BULUT, Oya, DIK, Irmak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2015
Materias:
Virology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751131/
https://www.ncbi.nlm.nih.gov/pubmed/26290129
http://dx.doi.org/10.1292/jvms.15-0231
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author AVCI, Oguzhan
BULUT, Oya
DIK, Irmak
author_facet AVCI, Oguzhan
BULUT, Oya
DIK, Irmak
author_sort AVCI, Oguzhan
collection PubMed
description The aim of this study is to determine the effects of iPPOV on pro-inflammatory and anti-inflammatory cytokine levels in rats. iPPOV (1 ml/rat) was administered intraperitoneal route to 49 rats, except for 7 rats (Control, 0 group). Serum samples were collected from 7 rats at 1st, 2nd, 4th, 8th, 12th, 16th and 24th hr after treatments. Levels of TNF-α, IL-6, IL-12 and IL-10 were determined using ELISA. Administration of iPPOV stimulated TNF-α (16th and 24th hr) and IL-6 (12th, 16th and 24th hr) synthesis and caused fluctuations in IL-10 and IL-12 concentrations. In conclusion, increased cytokine levels could be attributed to immunomodulatory activity of iPPOV, however, detailed studies are required to fully understand effects of iPPOV on immune system.
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spelling pubmed-47511312016-02-26 Effects of inactive parapoxvirus ovis on cytokine levels in rats AVCI, Oguzhan BULUT, Oya DIK, Irmak J Vet Med Sci Virology The aim of this study is to determine the effects of iPPOV on pro-inflammatory and anti-inflammatory cytokine levels in rats. iPPOV (1 ml/rat) was administered intraperitoneal route to 49 rats, except for 7 rats (Control, 0 group). Serum samples were collected from 7 rats at 1st, 2nd, 4th, 8th, 12th, 16th and 24th hr after treatments. Levels of TNF-α, IL-6, IL-12 and IL-10 were determined using ELISA. Administration of iPPOV stimulated TNF-α (16th and 24th hr) and IL-6 (12th, 16th and 24th hr) synthesis and caused fluctuations in IL-10 and IL-12 concentrations. In conclusion, increased cytokine levels could be attributed to immunomodulatory activity of iPPOV, however, detailed studies are required to fully understand effects of iPPOV on immune system. The Japanese Society of Veterinary Science 2015-08-20 2016-01 /pmc/articles/PMC4751131/ /pubmed/26290129 http://dx.doi.org/10.1292/jvms.15-0231 Text en ©2016 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Virology
AVCI, Oguzhan
BULUT, Oya
DIK, Irmak
Effects of inactive parapoxvirus ovis on cytokine levels in rats
title Effects of inactive parapoxvirus ovis on cytokine levels in rats
title_full Effects of inactive parapoxvirus ovis on cytokine levels in rats
title_fullStr Effects of inactive parapoxvirus ovis on cytokine levels in rats
title_full_unstemmed Effects of inactive parapoxvirus ovis on cytokine levels in rats
title_short Effects of inactive parapoxvirus ovis on cytokine levels in rats
title_sort effects of inactive parapoxvirus ovis on cytokine levels in rats
topic Virology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751131/
https://www.ncbi.nlm.nih.gov/pubmed/26290129
http://dx.doi.org/10.1292/jvms.15-0231
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AT bulutoya effectsofinactiveparapoxvirusovisoncytokinelevelsinrats
AT dikirmak effectsofinactiveparapoxvirusovisoncytokinelevelsinrats

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