Protective efficacy of stockpiled vaccine against H5N8 highly pathogenic avian influenza virus isolated from a chicken in Kumamoto prefecture, Japan, in 2014

H5 highly pathogenic avian influenza (HPAI) viruses have spread worldwide, and antigenic variants of different clades have been selected. In this study, the national stockpiled vaccine prepared from A/duck/Hokkaido/Vac-1/2004 (H5N1) strain was evaluated for the protective efficacy against H5N8 HPAI...

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Detalles Bibliográficos
Autores principales: GAMOH, Koichiro, NAKAMIZO, Mari, OKAMATSU, Masatoshi, SAKODA, Yoshihiro, KIDA, Hiroshi, SUZUKI, Shoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2015
Materias:
Avian Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751133/
https://www.ncbi.nlm.nih.gov/pubmed/26290130
http://dx.doi.org/10.1292/jvms.15-0324
Descripción
Sumario:H5 highly pathogenic avian influenza (HPAI) viruses have spread worldwide, and antigenic variants of different clades have been selected. In this study, the national stockpiled vaccine prepared from A/duck/Hokkaido/Vac-1/2004 (H5N1) strain was evaluated for the protective efficacy against H5N8 HPAI virus isolated in Kumamoto prefecture, Japan, in April 2014. In the challenge test, all of the vaccinated chickens survived without showing any clinical signs and reduced virus shedding. It was concluded that the present stockpiled vaccine was effective against the H5N8 HPAI virus.

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