A Comparative Oncology Study of Iniparib Defines Its Pharmacokinetic Profile and Biological Activity in a Naturally-Occurring Canine Cancer Model

Development of iniparib as an anti-cancer agent was hindered in part by lingering questions regarding its mechanism of action, the activity of its metabolites, and their potential accumulation in tumors. Due to strong similarities in metabolism of iniparib between humans and dogs, a veterinary clini...

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Detalles Bibliográficos
Autores principales: Saba, Corey, Paoloni, Melissa, Mazcko, Christina, Kisseberth, William, Burton, Jenna H., Smith, Annette, Wilson-Robles, Heather, Allstadt, Sara, Vail, David, Henry, Carolyn, Lana, Susan, Ehrhart, E. J., Charles, Brad, Kent, Michael, Lawrence, Jessica, Burgess, Kristine, Borgatti, Antonella, Suter, Steve, Woods, Paul, Gordon, Ira, Vrignaud, Patricia, Khanna, Chand, LeBlanc, Amy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751284/
https://www.ncbi.nlm.nih.gov/pubmed/26866698
http://dx.doi.org/10.1371/journal.pone.0149194

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