CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3(+) T Cells

Current models of Foxp3(+) regulatory T cell (Treg) development involve CCR7-mediated migration of thymocytes into the thymus medulla to enable essential interactions with medullary epithelium. However, increased Foxp3(+) thymic Treg numbers in Ccr7(−/−) mice challenge this view, and the role of CCR...

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Detalles Bibliográficos
Autores principales: Cowan, Jennifer E., McCarthy, Nicholas I., Anderson, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751304/
https://www.ncbi.nlm.nih.gov/pubmed/26832402
http://dx.doi.org/10.1016/j.celrep.2016.01.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751304/
https://www.ncbi.nlm.nih.gov/pubmed/26832402
http://dx.doi.org/10.1016/j.celrep.2016.01.003

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