Management of Multiple Myeloma Complicated by Hepatitis C Virus Reactivation: The Role of New Antiviral Therapy

Reactivation of chronic hepatitis C virus (HCV) infection has been reported in cancer patients receiving chemotherapy. In this study, we report the first case, to our knowledge, of thalidomide-induced acute exacerbation and reactivation of chronic HCV infection complicating management of multiple my...

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Detalles Bibliográficos
Autores principales: Mahale, Parag, Thomas, Sheeba K., Kyvernitakis, Andreas, Torres, Harrys A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751339/
https://www.ncbi.nlm.nih.gov/pubmed/26885541
http://dx.doi.org/10.1093/ofid/ofv211
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author Mahale, Parag
Thomas, Sheeba K.
Kyvernitakis, Andreas
Torres, Harrys A.
author_facet Mahale, Parag
Thomas, Sheeba K.
Kyvernitakis, Andreas
Torres, Harrys A.
author_sort Mahale, Parag
collection PubMed
description Reactivation of chronic hepatitis C virus (HCV) infection has been reported in cancer patients receiving chemotherapy. In this study, we report the first case, to our knowledge, of thalidomide-induced acute exacerbation and reactivation of chronic HCV infection complicating management of multiple myeloma. Sofosbuvir-based antiviral therapy helped achieve viral clearance and normalization of liver enzymes, thus allowing access to future potentially life-saving chemotherapy agents.
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spelling pubmed-47513392016-02-16 Management of Multiple Myeloma Complicated by Hepatitis C Virus Reactivation: The Role of New Antiviral Therapy Mahale, Parag Thomas, Sheeba K. Kyvernitakis, Andreas Torres, Harrys A. Open Forum Infect Dis Brief Reports Reactivation of chronic hepatitis C virus (HCV) infection has been reported in cancer patients receiving chemotherapy. In this study, we report the first case, to our knowledge, of thalidomide-induced acute exacerbation and reactivation of chronic HCV infection complicating management of multiple myeloma. Sofosbuvir-based antiviral therapy helped achieve viral clearance and normalization of liver enzymes, thus allowing access to future potentially life-saving chemotherapy agents. Oxford University Press 2015-12-28 /pmc/articles/PMC4751339/ /pubmed/26885541 http://dx.doi.org/10.1093/ofid/ofv211 Text en © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Mahale, Parag
Thomas, Sheeba K.
Kyvernitakis, Andreas
Torres, Harrys A.
Management of Multiple Myeloma Complicated by Hepatitis C Virus Reactivation: The Role of New Antiviral Therapy
title Management of Multiple Myeloma Complicated by Hepatitis C Virus Reactivation: The Role of New Antiviral Therapy
title_full Management of Multiple Myeloma Complicated by Hepatitis C Virus Reactivation: The Role of New Antiviral Therapy
title_fullStr Management of Multiple Myeloma Complicated by Hepatitis C Virus Reactivation: The Role of New Antiviral Therapy
title_full_unstemmed Management of Multiple Myeloma Complicated by Hepatitis C Virus Reactivation: The Role of New Antiviral Therapy
title_short Management of Multiple Myeloma Complicated by Hepatitis C Virus Reactivation: The Role of New Antiviral Therapy
title_sort management of multiple myeloma complicated by hepatitis c virus reactivation: the role of new antiviral therapy
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751339/
https://www.ncbi.nlm.nih.gov/pubmed/26885541
http://dx.doi.org/10.1093/ofid/ofv211
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