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Multisensory body representation in autoimmune diseases

Body representation has been linked to the processing and integration of multisensory signals. An outstanding example of the pivotal role played by multisensory mechanisms in body representation is the Rubber Hand Illusion (RHI). In this paradigm, multisensory stimulation induces a sense of ownershi...

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Autores principales: Finotti, Gianluca, Costantini, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751570/
https://www.ncbi.nlm.nih.gov/pubmed/26867786
http://dx.doi.org/10.1038/srep21074
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author Finotti, Gianluca
Costantini, Marcello
author_facet Finotti, Gianluca
Costantini, Marcello
author_sort Finotti, Gianluca
collection PubMed
description Body representation has been linked to the processing and integration of multisensory signals. An outstanding example of the pivotal role played by multisensory mechanisms in body representation is the Rubber Hand Illusion (RHI). In this paradigm, multisensory stimulation induces a sense of ownership over a fake limb. Previous work has shown high interindividual differences in the susceptibility to the RHI. The origin of this variability remains largely unknown. Given the tight and bidirectional communication between the brain and the immune system, we predicted that the origin of this variability could be traced, in part, to the immune system’s functioning, which is altered by several clinical conditions, including Coeliac Disease (CD). Consistent with this prediction, we found that the Rubber Hand Illusion is stronger in CD patients as compared to healthy controls. We propose a biochemical mechanism accounting for the dependency of multisensory body representation upon the Immune system. Our finding has direct implications for a range of neurological, psychiatric and immunological conditions where alterations of multisensory integration, body representation and dysfunction of the immune system co-exist.
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spelling pubmed-47515702016-02-22 Multisensory body representation in autoimmune diseases Finotti, Gianluca Costantini, Marcello Sci Rep Article Body representation has been linked to the processing and integration of multisensory signals. An outstanding example of the pivotal role played by multisensory mechanisms in body representation is the Rubber Hand Illusion (RHI). In this paradigm, multisensory stimulation induces a sense of ownership over a fake limb. Previous work has shown high interindividual differences in the susceptibility to the RHI. The origin of this variability remains largely unknown. Given the tight and bidirectional communication between the brain and the immune system, we predicted that the origin of this variability could be traced, in part, to the immune system’s functioning, which is altered by several clinical conditions, including Coeliac Disease (CD). Consistent with this prediction, we found that the Rubber Hand Illusion is stronger in CD patients as compared to healthy controls. We propose a biochemical mechanism accounting for the dependency of multisensory body representation upon the Immune system. Our finding has direct implications for a range of neurological, psychiatric and immunological conditions where alterations of multisensory integration, body representation and dysfunction of the immune system co-exist. Nature Publishing Group 2016-02-12 /pmc/articles/PMC4751570/ /pubmed/26867786 http://dx.doi.org/10.1038/srep21074 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Finotti, Gianluca
Costantini, Marcello
Multisensory body representation in autoimmune diseases
title Multisensory body representation in autoimmune diseases
title_full Multisensory body representation in autoimmune diseases
title_fullStr Multisensory body representation in autoimmune diseases
title_full_unstemmed Multisensory body representation in autoimmune diseases
title_short Multisensory body representation in autoimmune diseases
title_sort multisensory body representation in autoimmune diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751570/
https://www.ncbi.nlm.nih.gov/pubmed/26867786
http://dx.doi.org/10.1038/srep21074
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