Identification of the epigenetic reader CBX2 as a potential drug target in advanced prostate cancer

BACKGROUND: While localized prostate cancer (PCa) can be effectively cured, metastatic disease inevitably progresses to a lethal state called castration-resistant prostate cancer (CRPC). Emerging evidence suggests that aberrant epigenetic repression by the polycomb group (PcG) complexes fuels PCa pr...

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Detalles Bibliográficos
Autores principales: Clermont, Pier-Luc, Crea, Francesco, Chiang, Yan Ting, Lin, Dong, Zhang, Amy, Wang, James Z. L., Parolia, Abhijit, Wu, Rebecca, Xue, Hui, Wang, Yuwei, Ding, Jiarui, Thu, Kelsie L., Lam, Wan L., Shah, Sohrab P., Collins, Colin C., Wang, Yuzhuo, Helgason, Cheryl D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751702/
https://www.ncbi.nlm.nih.gov/pubmed/26877821
http://dx.doi.org/10.1186/s13148-016-0182-9

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