Does VEGF facilitate local tumor growth and spread into the abdominal cavity by suppressing endothelial cell adhesion, thus increasing vascular peritoneal permeability followed by ascites production in ovarian cancer?

BACKGROUND: Ovarian cancer is mostly associated with pathologically regulated permeability of peritoneal vessels, leading to ascites. Here, we investigated the molecular regulation of endothelial permeability by the vascular endothelial growth factor (VEGF) and both tight and adherens junction prote...

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Detalles Bibliográficos
Autores principales: Bekes, Inga, Friedl, Thomas W. P., Köhler, Tanja, Möbus, Volker, Janni, Wolfgang, Wöckel, Achim, Wulff, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751711/
https://www.ncbi.nlm.nih.gov/pubmed/26868378
http://dx.doi.org/10.1186/s12943-016-0497-3

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